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    glh-4 ATP-dependent RNA helicase glh-4 [ Caenorhabditis elegans ]

    Gene ID: 171941, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glh-4
    Official Full Name
    ATP-dependent RNA helicase glh-4
    Primary source
    WormBase:WBGene00001601
    Locus tag
    CELE_T12F5.3
    See related
    AllianceGenome:WB:WBGene00001601
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables JUN kinase binding activity. Involved in gamete generation and regulation of cell population proliferation. Located in P granule. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glh-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (3727027..3731179)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pre-microRNA mir-8204 Neighboring gene PRELI/MSF1 domain-containing protein Neighboring gene putative histone-lysine N-methyltransferase lin-59 Neighboring gene RING-type domain-containing protein Neighboring gene HTH La-type RNA-binding domain-containing protein Neighboring gene Ribosome biogenesis protein NOP53

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of the Caenorhabditis elegans GLH family of P-granule proteins. Spike C, et al. Genetics, 2008 Apr. PMID 18430929, Free PMC Article
    2. P granules extend the nuclear pore complex environment in the C. elegans germ line. Updike DL, et al. J Cell Biol, 2011 Mar 21. PMID 21402789, Free PMC Article
    3. GLH-1, the C. elegans P granule protein, is controlled by the JNK KGB-1 and by the COP9 subunit CSN-5. Orsborn AM, et al. Development, 2007 Sep. PMID 17699606
    4. The GLH proteins, Caenorhabditis elegans P granule components, associate with CSN-5 and KGB-1, proteins necessary for fertility, and with ZYX-1, a predicted cytoskeletal protein. Smith P, et al. Dev Biol, 2002 Nov 15. PMID 12435362
    5. Germ-granule components prevent somatic development in the C. elegans germline. Updike DL, et al. Curr Biol, 2014 May 5. PMID 24746798, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase glh-4
    NP_491207.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3727027..3731179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058806.6 → NP_491207.3  ATP-dependent RNA helicase glh-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491207.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44758, O76743
      Conserved Domains (5) summary
      PTZ00368
      Location:572 → 685
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      smart00487
      Location:751 → 968
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:964 → 1104
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00098
      Location:570 → 587
      zf-CCHC; Zinc knuckle
      cl21455
      Location:743 → 938
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76743.2

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