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    egl-18 Putative transcription factor egl-18 [ Caenorhabditis elegans ]

    Gene ID: 176992, updated on 9-Dec-2024

    Summary

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    Official Symbol
    egl-18
    Official Full Name
    Putative transcription factor egl-18
    Primary source
    WormBase:WBGene00001186
    Locus tag
    CELE_F55A8.1
    See related
    AllianceGenome:WB:WBGene00001186
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate specification; membrane fusion; and nematode larval development. Located in nucleus. Is expressed in several structures, including ABprpppppaa; body wall muscle cell from MS lineage; nervous system; seam cell; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See egl-18 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (1913446..1917838)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transcription factor elt-6 Neighboring gene DENN domain type RAB GEF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans embryonic fate specification factor EGL-18 (GATA) is reutilized downstream of Wnt signaling to maintain a population of larval progenitor cells. Gorrepati L, et al. Worm, 2015 Jan-Mar. PMID 26430560, Free PMC Article
    2. Cell fates and fusion in the C. elegans vulval primordium are regulated by the EGL-18 and ELT-6 GATA factors -- apparent direct targets of the LIN-39 Hox protein. Koh K, et al. Development, 2002 Nov. PMID 12399309
    3. ELT-5 and ELT-6 are required continuously to regulate epidermal seam cell differentiation and cell fusion in C. elegans. Koh K, et al. Development, 2001 Aug. PMID 11532911
    4. Identification of evolutionarily conserved promoter elements and amino acids required for function of the C. elegans beta-catenin homolog BAR-1. Natarajan L, et al. Dev Biol, 2004 Aug 15. PMID 15282167
    5. Response to Tonsaker et al. Kim SK, et al. Mech Ageing Dev, 2012 Jan. PMID 22155122, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. egl-18 and elt-6 are necessary for larval seam cell specification, and for hypodermal to seam cell fate transformations induced by ectopic Wnt pathway overactivation.
      Title: C. elegans GATA factors EGL-18 and ELT-6 function downstream of Wnt signaling to maintain the progenitor fate during larval asymmetric divisions of the seam cells.
    2. egl-18/elt-6 prevent fusion and promote cell proliferation at multiple steps of vulval development
      Title: The nT1 translocation separates vulval regulatory elements from the egl-18 and elt-6 GATA factor genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Putative transcription factor egl-18
    NP_001294448.1
    • Confirmed by transcript evidence
    NP_500143.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1913446..1917838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307519.4 → NP_001294448.1  Putative transcription factor egl-18 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294448.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PMB4
      Conserved Domains (1) summary
      cd00202
      Location:268 → 320
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    2. NM_067742.8 → NP_500143.1  Putative transcription factor egl-18 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500143.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGF4, Q6S9C1, U4PMB4
      Conserved Domains (1) summary
      cd00202
      Location:265 → 317
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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