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    gln-2 putative glutamine synthetase [ Caenorhabditis elegans ]

    Gene ID: 176407, updated on 2-Nov-2024

    Summary

    Official Symbol
    gln-2
    Official Full Name
    putative glutamine synthetase
    Primary source
    WormBase:WBGene00001603
    Locus tag
    CELE_K03H1.1
    See related
    AllianceGenome:WB:WBGene00001603
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutamine synthetase activity. Predicted to be involved in glutamine biosynthetic process. Predicted to be active in cytoplasm. Is expressed in germ line. Human ortholog(s) of this gene implicated in congenital glutamine deficiency; epilepsy (multiple); heart disease; and neurodegenerative disease (multiple). Orthologous to human GLUL (glutamate-ammonia ligase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See gln-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (9943243..9944823, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Ovule protein Neighboring gene Wsv008 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Ovule protein Neighboring gene L-fucokinase domain-containing protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutamine synthetase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutamine synthetase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in glutamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glutamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    putative glutamine synthetase
    NP_499208.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9943243..9944823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066807.4NP_499208.1  putative glutamine synthetase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499208.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34497
      Conserved Domains (3) summary
      PLN02284
      Location:10366
      PLN02284; glutamine synthetase
      pfam00120
      Location:132362
      Gln-synt_C; Glutamine synthetase, catalytic domain
      pfam03951
      Location:33107
      Gln-synt_N; Glutamine synthetase, beta-Grasp domain