rpa-1 putative replication factor A 73 kDa subunit [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rpa-1
Official Full Name: putative replication factor A 73 kDa subunit
Primary source: WormBase:WBGene00017546
Locus tag: CELE_F18A1.5
See related: AllianceGenome:WB:WBGene00017546
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables enzyme binding activity. Involved in positive regulation of nematode male tail tip morphogenesis. Located in nucleoplasm. Is expressed in germ line and pharynx. Orthologous to human RPA1 (replication protein A1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rpa-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 9

Sequence:: Chromosome: II; NC_003280.10 (7664582..7667110)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we found that Caenorhabditis elegans replication protein A, a single-stranded DNA binding protein, suppresses the reiterative behavior of HIM-6 and induces unidirectional, processive unwinding, possibly through a direct interaction between the proteins.
Title: Molecular characteristics of reiterative DNA unwinding by the Caenorhabditis elegans RecQ helicase.
Data show that replication factor A (RPA-1) and DNA repair protein RAD51 (RAD-51) colocalization for hours post-microirradiation throughout the germline.
Title: Differential RPA-1 and RAD-51 recruitment in vivo throughout the C. elegans germline, as revealed by laser microirradiation.
analysis of physical and functional interactions of Caenorhabditis elegans WRN-1 helicase with RPA-1
Title: Physical and functional interactions of Caenorhabditis elegans WRN-1 helicase with RPA-1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F18A1.5 (e-PCR)
- UniSTS:309809

F18A1.7 (e-PCR)
- UniSTS:309811

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables single-stranded telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA unwinding involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance via telomerase	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of DNA replication factor A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of DNA replication factor A complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative replication factor A 73 kDa subunit

NP_495606.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7664582..7667110

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063205.7 → NP_495606.1 putative replication factor A 73 kDa subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495606.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19537

Conserved Domains (4) summary

cd04474
Location:225 → 325

RPA1_DBD_A; RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...

cd04475
Location:353 → 455

RPA1_DBD_B; RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...

TIGR00617
Location:12 → 648

rpa1; replication factor-a protein 1 (rpa1)

pfam08646
Location:498 → 642

Rep_fac-A_C; Replication factor-A C terminal domain