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    elpc-3 Elongator complex protein 3 [ Caenorhabditis elegans ]

    Gene ID: 179669, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elpc-3
    Official Full Name
    Elongator complex protein 3
    Primary source
    WormBase:WBGene00014123
    Locus tag
    CELE_ZK863.3
    See related
    AllianceGenome:WB:WBGene00014123
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphorylase kinase regulator activity. Involved in several processes, including gene expression; olfactory learning; and vulval development. Predicted to be part of elongator holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including CAN; HSN; amphid neurons; pharynx; and vulva. Used to study Riley-Day syndrome. Orthologous to human ELP3 (elongator acetyltransferase complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See elpc-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (12179497..12181410, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene U6 snRNA-specific terminal uridylyltransferase Neighboring gene G protein-coupled receptor Neighboring gene UPAR/Ly6 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation. Solinger JA, et al. PLoS Genet, 2010 Jan 22. PMID 20107598, Free PMC Article
    2. Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants. Chen C, et al. PLoS Genet, 2009 Jul. PMID 19593383, Free PMC Article
    3. Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. Pastore C, et al. J Biol Chem, 2012 Jan 13. PMID 22065580, Free PMC Article
    4. The protein kinase G orthologs, EGL-4 and PKG-2, mediate serotonin-induced paralysis of C. elegans. Olson A, et al. MicroPubl Biol, 2019 May 24. PMID 32550449, Free PMC Article
    5. Alanine tRNAs Translate Environment Into Behavior in Caenorhabditis elegans. Fernandes De Abreu DA, et al. Front Cell Dev Biol, 2020. PMID 33195203, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Elpc1 and elpc3 complex regulates neuronal alpha-tubulin acetylation.
      Title: The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorylase kinase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA uridine(34) acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Elongator complex protein 3
    NP_506055.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12179497..12181410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073654.5 → NP_506055.2  Elongator complex protein 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506055.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23651
      Conserved Domains (1) summary
      TIGR01211
      Location:17 → 542
      ELP3; radical SAM enzyme/protein acetyltransferase, ELP3 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23651.2

    Gene LinkOut

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