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    ikke-1 Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1 [ Caenorhabditis elegans ]

    Gene ID: 176278, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ikke-1
    Official Full Name
    Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1
    Primary source
    WormBase:WBGene00011299
    Locus tag
    CELE_R107.4
    See related
    AllianceGenome:WB:WBGene00011299
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in protein phosphorylation and regulation of autophagy. Located in cytoplasm. Is expressed in anal sphincter muscle; intestinal muscle; and oocyte. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ikke-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (9046039..9050700, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Sodium-dependent high-affinity dicarboxylate transporter 2 Neighboring gene ATP-dependent (S)-NAD(P)H-hydrate dehydratase Neighboring gene Uncharacterized protein Neighboring gene Protein CLASP-2;TOG domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ALLO-1- and IKKE-1-dependent positive feedback mechanism promotes the initiation of paternal mitochondrial autophagy. Sasaki T, et al. Nat Commun, 2024 Feb 17. PMID 38368448, Free PMC Article
    2. The protein kinases of Caenorhabditis elegans: a model for signal transduction in multicellular organisms. Plowman GD, et al. Proc Natl Acad Sci U S A, 1999 Nov 23. PMID 10570119, Free PMC Article
    3. The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans. Sato M, et al. Nat Cell Biol, 2018 Jan. PMID 29255173
    4. Activation of SKN-1 by novel kinases in Caenorhabditis elegans. Kell A, et al. Free Radic Biol Med, 2007 Dec 1. PMID 17964427, Free PMC Article
    5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. It has been proposed that ALLO-1 is the allophagy receptor whose function is regulated by IKKE-1-dependent phosphorylation.
      Title: The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1
    NP_001359523.1
    • Confirmed by transcript evidence
    NP_001379435.1
    • Confirmed by transcript evidence
    NP_871627.1
    • Confirmed by transcript evidence
    NP_871628.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9046039..9050700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_181899.7 → NP_871628.1  Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871628.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P32742
      Conserved Domains (2) summary
      COG0515
      Location:25 → 404
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cl21453
      Location:27 → 275
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001372639.1 → NP_001359523.1  Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl21453
      Location:27 → 275
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001392170.1 → NP_001379435.1  Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl21453
      Location:27 → 275
      PKc_like; Protein Kinases, catalytic domain

    4. NM_181898.4 → NP_871627.1  Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871627.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P32741, P32742, Q5FC85
      Conserved Domains (2) summary
      COG0515
      Location:25 → 404
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cl21453
      Location:27 → 275
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32742.5

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