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    haly-1 Histidine ammonia-lyase [ Caenorhabditis elegans ]

    Gene ID: 181279, updated on 9-Dec-2024

    Summary

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    Official Symbol
    haly-1
    Official Full Name
    Histidine ammonia-lyase
    Primary source
    WormBase:WBGene00009813
    Locus tag
    CELE_F47B10.2
    See related
    AllianceGenome:WB:WBGene00009813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histidine ammonia-lyase activity. Involved in L-histidine catabolic process. Predicted to be located in cytoplasm. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in histidinemia. Orthologous to human HAL (histidine ammonia-lyase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See haly-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (10893567..10896598, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Phage protein Neighboring gene Uncharacterized protein Neighboring gene ADH_N domain-containing protein Neighboring gene Serpentine Receptor, class T Neighboring gene Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of mutations in Caenorhabditis elegans that cause resistance to high levels of dietary zinc and analysis using a genomewide map of single nucleotide polymorphisms scored by pyrosequencing. Bruinsma JJ, et al. Genetics, 2008 Jun. PMID 18505880, Free PMC Article
    2. Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans. Murphy JT, et al. PLoS Genet, 2011 Mar. PMID 21455490, Free PMC Article
    3. SKN-1 regulates stress resistance downstream of amino catabolism pathways. Frankino PA, et al. iScience, 2022 Jul 15. PMID 35784796, Free PMC Article
    4. The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation. Warnhoff K, et al. PLoS Genet, 2014 Oct. PMID 25330323, Free PMC Article
    5. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histidine ammonia-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histidine ammonia-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-histidine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-histidine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-histidine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in L-histidine catabolic process to glutamate and formamide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-histidine catabolic process to glutamate and formate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-histidine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Histidine ammonia-lyase
    NP_509820.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10893567..10896598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077419.7 → NP_509820.1  Histidine ammonia-lyase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509820.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20502
      Conserved Domains (3) summary
      pfam12053
      Location:1 → 75
      DUF3534; Domain of unknown function (DUF3534)
      cl00013
      Location:127 → 632
      Lyase_I_like; Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions
      cl01247
      Location:87 → 164
      FliO; Flagellar biosynthesis protein, FliO
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20502.1

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