ndk-1 Nucleoside diphosphate kinase [Caenorhabditis elegans] - Gene

Summary

Official Symbol: ndk-1
Official Full Name: Nucleoside diphosphate kinase
Primary source: WormBase:WBGene00009119
Locus tag: CELE_F25H2.5
See related: AllianceGenome:WB:WBGene00009119
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables identical protein binding activity and protein histidine kinase activity. Involved in several processes, including negative regulation of axon regeneration; positive regulation of vulval development; and regulation of engulfment of apoptotic cell. Is expressed in several structures, including excretory cell; hypodermis; intestine; nervous system; and non-striated muscle. Human ortholog(s) of this gene implicated in neuroblastoma; ovary epithelial cancer; and teratoma. Orthologous to several human genes including NME2 (NME/NM23 nucleoside diphosphate kinase 2); NME1-NME2 (NME1-NME2 readthrough); and NME2P1 (NME2 pseudogene 1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Ndk-1 loss-of-function mutants show defects in the morphogenesis of the vulva.
Title: The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein histidine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleoside triphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed

NP_001379178.1

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