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    asp-3 Aspartic protease 3 [ Caenorhabditis elegans ]

    Gene ID: 180947, updated on 9-Dec-2024

    Summary

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    Official Symbol
    asp-3
    Official Full Name
    Aspartic protease 3
    Primary source
    WormBase:WBGene00000216
    Locus tag
    CELE_H22K11.1
    See related
    AllianceGenome:WB:WBGene00000216
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Involved in programmed necrotic cell death. Located in lysosome. Is expressed in intestine and uterus. Orthologous to human NAPSA (napsin A aspartic peptidase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See asp-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (6791064..6792709)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Glycoside hydrolase 35 catalytic domain-containing protein Neighboring gene CADG domain-containing protein;Dystroglycan-type cadherin-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteolytic mechanisms in necrotic cell death and neurodegeneration. Artal-Sanz M, et al. FEBS Lett, 2005 Jun 13. PMID 15943973
    2. A Disease Model of Muscle Necrosis Caused by Aeromonas dhakensis Infection in Caenorhabditis elegans. Chen PL, et al. Front Microbiol, 2016. PMID 28101079, Free PMC Article
    3. Paralysis of nematodes: shifts in the transcriptome of the nematode-trapping fungus Monacrosporium haptotylum during infection of Caenorhabditis elegans. Fekete C, et al. Environ Microbiol, 2008 Feb. PMID 18028414
    4. Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1. Tcherepanova I, et al. J Biol Chem, 2000 Aug 25. PMID 10854422
    5. First identification of a phosphorylcholine-substituted protein from Caenorhabditis elegans: isolation and characterization of the aspartyl protease ASP-6. Lochnit G, et al. Biol Chem, 2006 Oct-Nov. PMID 17081123

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in programmed necrotic cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aspartic protease 3
    NP_509142.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6791064..6792709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076741.8 → NP_509142.2  Aspartic protease 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509142.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P55956, Q9TXI5
      Conserved Domains (2) summary
      pfam00026
      Location:68 → 393
      Asp; Eukaryotic aspartyl protease
      cl11403
      Location:59 → 393
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55956.3

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