unc-59 Septin [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-59
Official Full Name: Septin
Primary source: WormBase:WBGene00006793
Locus tag: CELE_W09C5.2
See related: AllianceGenome:WB:WBGene00006793
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activity and molecular adaptor activity. Involved in egg-laying behavior; locomotion; and post-embryonic development. Located in cleavage furrow and midbody. Is expressed in several structures, including buccal cavity; distal tip cell; germ line; pharynx; and sperm. Orthologous to several human genes including SEPTIN7 (septin 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-59 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (13629227..13633492)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

may be generally required for developmental migrations and pathfinding
Title: A role for septins in cellular and axonal migration in C. elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W09C5.1 (e-PCR)
- UniSTS:312962

W09C5.2 (e-PCR)
- UniSTS:318623

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Septin

NP_493388.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

13629227..13633492

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060987.6 → NP_493388.1 Septin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493388.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U334

Conserved Domains (2) summary

cd01850
Location:44 → 318

CDC_Septin; CDC/Septin GTPase family

pfam13863
Location:328 → 401

DUF4200; Domain of unknown function (DUF4200)