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    ufd-3 PUL domain-containing protein;Ubiquitin fusion degradation protein 3 homolog [ Caenorhabditis elegans ]

    Gene ID: 3565222, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ufd-3
    Official Full Name
    PUL domain-containing protein;Ubiquitin fusion degradation protein 3 homolog
    Primary source
    WormBase:WBGene00007333
    Locus tag
    CELE_C05C10.6
    See related
    AllianceGenome:WB:WBGene00007333
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and ubiquitin recycling. Located in cytoplasm. Is expressed in intestine and nervous system. Orthologous to human PLAA (phospholipase A2 activating protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ufd-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (9940753..9944107)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Cytochrome P450;USH2A;Uncharacterized protein Neighboring gene FAD synthase;Molybdenum cofactor biosynthesis protein-like region Neighboring gene Zinc finger protein egl-43 Neighboring gene Thymidylate kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of C-terminal adaptors, UFD-2 and UFD-3, of CDC-48 on the polyglutamine aggregation in C. elegans. Murayama Y, et al. Biochem Biophys Res Commun, 2015 Mar 27. PMID 25721663
    2. Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis. Sasagawa Y, et al. Genes Cells, 2010 Dec. PMID 20977550
    3. Identification of a spontaneously arising variant affecting thermotaxis behavior in a recombinant inbred Caenorhabditis elegans line. Yeon J, et al. G3 (Bethesda), 2023 Sep 30. PMID 37572357, Free PMC Article
    4. ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans. Sasagawa Y, et al. Genes Cells, 2007 Sep. PMID 17825049
    5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UFD-2 and UFD-3 bind to CDC-48 in a mutually exclusive manner.CDC-48 preferentially interacts with UFD-3 in C. elegans under the physiological condition.
      Title: Characterization of C-terminal adaptors, UFD-2 and UFD-3, of CDC-48 on the polyglutamine aggregation in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PUL domain-containing protein;Ubiquitin fusion degradation protein 3 homolog
    NP_001254232.1
    • Confirmed by transcript evidence
    NP_496146.1
    • Confirmed by transcript evidence
    NP_496147.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9940753..9944107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063746.5 → NP_496147.1  Ubiquitin fusion degradation protein 3 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496147.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFK5
      Conserved Domains (5) summary
      COG2319
      Location:23 → 275
      WD40; WD40 repeat [General function prediction only]
      pfam08324
      Location:587 → 836
      PUL; PUL domain
      pfam09070
      Location:420 → 472
      PFU; PFU (PLAA family ubiquitin binding)
      sd00039
      Location:77 → 115
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:22 → 318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_063745.4 → NP_496146.1  Ubiquitin fusion degradation protein 3 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496146.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EES6, G5EFK5
      Conserved Domains (4) summary
      sd00039
      Location:77 → 115
      7WD40; WD40 repeat [structural motif]
      pfam08324
      Location:589 → 838
      PUL; PUL domain
      pfam09070
      Location:422 → 474
      PFU; PFU (PLAA family ubiquitin binding)
      cl25539
      Location:22 → 320
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001267303.3 → NP_001254232.1  PUL domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254232.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I2HAD6
      Conserved Domains (1) summary
      pfam08324
      Location:4 → 201
      PUL; PUL domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EES6.1

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