snf-6 Sodium-dependent acetylcholine transporter [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: snf-6
Official Full Name: Sodium-dependent acetylcholine transporter
Primary source: WormBase:WBGene00004905
Locus tag: CELE_M01G5.5
See related: AllianceGenome:WB:WBGene00004905
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables PDZ domain binding activity and acetylcholine transmembrane transporter activity. Involved in acetylcholine transport; choline transport; and positive regulation of locomotion. Predicted to be located in postsynaptic membrane. Predicted to be active in plasma membrane. Is expressed in anal depressor muscle; anal sphincter muscle; body wall musculature; intestinal muscle; and vulval muscle. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in hyperekplexia 3 and obesity. Orthologous to human SLC6A14 (solute carrier family 6 member 14) and SLC6A5 (solute carrier family 6 member 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See snf-6 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 11

Sequence:: Chromosome: III; NC_003281.10 (1519962..1532827, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mutations result in phenotypes indistinguishable from those of the dystrophin-glycoprotein complex (DSC) mutants, and snf-6 encodes a novel acetylcholine/choline transporter
Title: SNF-6 is an acetylcholine transporter interacting with the dystrophin complex in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M01G5.5 (e-PCR)
- UniSTS:320108

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables acetylcholine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amino acid:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neurotransmitter:sodium symporter activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetylcholine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in choline transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glycine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine transport	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular synaptic transmission	NAS Non-traceable Author Statement more info	PubMed
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter uptake	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	NAS Non-traceable Author Statement more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sodium-dependent acetylcholine transporter

NP_001367976.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

1519962..1532827 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381736.1 → NP_001367976.1 Sodium-dependent acetylcholine transporter [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O76689, Q49RB2