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    swan-2 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179875, updated on 9-Dec-2024

    Summary

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    Official Symbol
    swan-2
    Official Full Name
    WD_REPEATS_REGION domain-containing protein
    Primary source
    WormBase:WBGene00009976
    Locus tag
    CELE_F53C11.7
    See related
    AllianceGenome:WB:WBGene00009976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in response to heat and response to osmotic stress. Predicted to be active in nucleus. Is expressed in head; intestine; nervous system; non-striated muscle; and reproductive system. Orthologous to human DCAF7 (DDB1 and CUL4 associated factor 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See swan-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (13800976..13804281, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene USP domain-containing protein;Zf-C3H1 domain-containing protein Neighboring gene Fibronectin type-III domain-containing protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SWAN-1, a Caenorhabditis elegans WD repeat protein of the AN11 family, is a negative regulator of Rac GTPase function. Yang Y, et al. Genetics, 2006 Dec. PMID 16980389, Free PMC Article
    2. The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. Ritterhoff S, et al. EMBO J, 2010 Nov 17. PMID 20940704, Free PMC Article
    3. The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. Kim Y, et al. Genes Dev, 2008 Sep 15. PMID 18794348, Free PMC Article
    4. Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Mehta R, et al. Science, 2009 May 29. PMID 19372390, Free PMC Article
    5. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in response to heat IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to osmotic stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD_REPEATS_REGION domain-containing protein
    NP_506417.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13800976..13804281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074016.9 → NP_506417.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506417.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93759
      Conserved Domains (2) summary
      sd00039
      Location:156 → 199
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:149 → 431
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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