gcy-8 Receptor-type guanylate cyclase gcy-8 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: gcy-8
Official Full Name: Receptor-type guanylate cyclase gcy-8
Primary source: WormBase:WBGene00001535
Locus tag: CELE_C49H3.1
See related: AllianceGenome:WB:WBGene00001535
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables guanylate cyclase activity. Involved in several processes, including microvillus organization; thermosensory behavior; and thermotaxis. Located in microvillus membrane and neuron projection terminus. Is expressed in AFDL and AFDR. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables guanylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in detection of temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in microvillus organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microvillus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor guanylyl cyclase signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in thermosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in microvillus membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

NP_501324.2

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The following sections contain reference sequences that belong to a specific genome build. Explain