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    ntr-2 Nematocin receptor 2 [ Caenorhabditis elegans ]

    Gene ID: 184471, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ntr-2
    Official Full Name
    Nematocin receptor 2
    Primary source
    WormBase:WBGene00008808
    Locus tag
    CELE_F14F4.1
    See related
    AllianceGenome:WB:WBGene00008808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in RMEV; ganglia; intestine; and oblique male muscle. Human ortholog(s) of this gene implicated in autism spectrum disorder; hypertension; mood disorder (multiple); nephrogenic diabetes insipidus (multiple); and nephrogenic syndrome of inappropriate antidiuresis. Orthologous to several human genes including AVPR1A (arginine vasopressin receptor 1A); AVPR1B (arginine vasopressin receptor 1B); and AVPR2 (arginine vasopressin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ntr-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (14924974..14928954, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene Multidrug resistance-associated protein 5 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An oxytocin-dependent social interaction between larvae and adult C. elegans. Scott E, et al. Sci Rep, 2017 Aug 31. PMID 28860630, Free PMC Article
    2. The long and the short of it - a perspective on peptidergic regulation of circuits and behaviour. Jékely G, et al. J Exp Biol, 2018 Feb 8. PMID 29439060
    3. System-wide mapping of peptide-GPCR interactions in C. elegans. Beets I, et al. Cell Rep, 2023 Sep 26. PMID 37656621, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nematocin receptor 2
    NP_510477.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14924974..14928954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078076.4 → NP_510477.1  Nematocin receptor 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510477.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62169
      Conserved Domains (1) summary
      pfam00001
      Location:37 → 323
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62169.1

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