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    atx-3 Ataxin-3 homolog [ Caenorhabditis elegans ]

    Gene ID: 180049, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atx-3
    Official Full Name
    Ataxin-3 homolog
    Primary source
    WormBase:WBGene00006446
    Locus tag
    CELE_F28F8.6
    See related
    AllianceGenome:WB:WBGene00006446
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cysteine-type deubiquitinase activity. Involved in chemical synaptic transmission. Located in cytoplasm and nucleus. Is expressed in several structures, including coelomocyte; head; hypodermis; reproductive system; and somatic nervous system. Used to study Machado-Joseph disease. Human ortholog(s) of this gene implicated in Machado-Joseph disease and late onset Parkinson's disease. Orthologous to human ATXN3 (ataxin 3) and ATXN3L (ataxin 3 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See atx-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (15575498..15577443, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Coiled-coil domain-containing protein mdt-28 Neighboring gene Uncharacterized protein Neighboring gene ELM2 domain-containing protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expanded polyglutamines impair synaptic transmission and ubiquitin-proteasome system in Caenorhabditis elegans. Khan LA, et al. J Neurochem, 2006 Jul. PMID 16805848
    2. Functional genomics and biochemical characterization of the C. elegans orthologue of the Machado-Joseph disease protein ataxin-3. Rodrigues AJ, et al. FASEB J, 2007 Apr. PMID 17234717
    3. Towards a structural understanding of the fibrillization pathway in Machado-Joseph's disease: trapping early oligomers of non-expanded ataxin-3. Gales L, et al. J Mol Biol, 2005 Oct 28. PMID 16194547
    4. NEDD8: a new ataxin-3 interactor. Ferro A, et al. Biochim Biophys Acta, 2007 Nov. PMID 17935801
    5. Absence of ataxin-3 leads to enhanced stress response in C. elegans. Rodrigues AJ, et al. PLoS One, 2011 Apr 19. PMID 21526185, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATX-3 is a Machado-Joseph disease deubiquitylase that couples longevity and proteostasis
      Title: The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis.
    2. ATX-3 interacts with both VCP/p97 worm homologs, CDC-48.1 and CDC-48.2 and the interaction domains were mapped.
      Title: ATX-3, CDC-48 and UBXN-5: a new trimolecular complex in Caenorhabditis elegans.
    3. ataxin-3 has a role in regulating core sets of genes involved in the ubiquitin-proteasome pathway, structure/motility, and signal transduction
      Title: Functional genomics and biochemical characterization of the C. elegans orthologue of the Machado-Joseph disease protein ataxin-3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ataxin-3 homolog
    NP_001379190.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15575498..15577443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392673.1 → NP_001379190.1  Ataxin-3 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17850
      Conserved Domains (1) summary
      pfam02099
      Location:15 → 161
      Josephin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17850.1

    Gene LinkOut

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