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    nhr-19 Nuclear hormone receptor family member nhr-19 [ Caenorhabditis elegans ]

    Gene ID: 174512, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-19
    Official Full Name
    Nuclear hormone receptor family member nhr-19
    Primary source
    WormBase:WBGene00003618
    Locus tag
    CELE_E02H1.7
    See related
    AllianceGenome:WB:WBGene00003618
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-19 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (9598180..9605526, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Adenylate kinase isoenzyme 6 homolog Neighboring gene Mitochondrial Ribosomal Protein, Large Neighboring gene Poly(A) polymerase Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships. Pathare PP, et al. PLoS Genet, 2012. PMID 22511885, Free PMC Article
    2. C30F12.4 influences oogenesis, fat metabolism, and lifespan in C. elegans. Wang L, et al. Protein Cell, 2016 Oct. PMID 27638466, Free PMC Article
    3. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    4. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor family member nhr-19
    NP_496066.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9598180..9605526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063665.7 → NP_496066.2  Nuclear hormone receptor family member nhr-19 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496066.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09528, Q8T3C7
      Conserved Domains (2) summary
      cd06960
      Location:80 → 155
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:268 → 447
      HOLI; Ligand binding domain of hormone receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09528.2

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