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    MATCAP1 microtubule associated tyrosine carboxypeptidase 1 [ Homo sapiens (human) ]

    Gene ID: 653319, updated on 27-Nov-2024

    Summary

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    Official Symbol
    MATCAP1provided by HGNC
    Official Full Name
    microtubule associated tyrosine carboxypeptidase 1provided by HGNC
    Primary source
    HGNC:HGNC:34408
    See related
    Ensembl:ENSG00000196123 MIM:619978; AllianceGenome:HGNC:34408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMCP1; KIAA0895L
    Summary
    Enables tubulin-tyrosine carboxypeptidase. Predicted to be involved in brain development. Is active in microtubule. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 12.4), adrenal (RPKM 12.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MATCAP1 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67175599..67183963, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72969893..72978247, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67209502..67217866, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67189519-67190420 Neighboring gene TNFRSF1A associated via death domain Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67195788-67196300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67196374-67197322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67197323-67198271 Neighboring gene F-box and leucine rich repeat protein 8 Neighboring gene Sharpr-MPRA regulatory region 11796 Neighboring gene heat shock transcription factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7588 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67206328-67206491 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67207408-67208330 Neighboring gene nucleolar protein 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67209861-67210290 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67211873-67212416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67212417-67212958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10956 Neighboring gene exocyst complex component 3 like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67225781-67226711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10958 Neighboring gene E2F transcription factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7593

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A family of carboxypeptidases catalyzing α- and β-tubulin tail processing and deglutamylation. Nicot S, et al. Sci Adv, 2023 Sep 15. PMID 37703372, Free PMC Article
    2. Posttranslational modification of microtubules by the MATCAP detyrosinase. Landskron L, et al. Science, 2022 May 20. PMID 35482892
    3. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. Aregger M, et al. Nat Metab, 2020 Jun. PMID 32694731, Free PMC Article
    4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article
    5. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin-tyrosine carboxypeptidase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microtubule-associated tyrosine carboxypeptidase 1
    Names
    KIAA0895 like
    microtubule-associated tyrosine carboxypeptidase
    tubulin metallocarboxypeptidase 1
    NP_001035805.1
    NP_001356609.1
    NP_001356610.1
    NP_001356611.1
    NP_001356613.1
    NP_001356614.1
    NP_001356615.1
    NP_001356616.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040715.2 → NP_001035805.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 1

      See identical proteins and their annotated locations for NP_001035805.1

      Status: VALIDATED

      Source sequence(s)
      AC074143, BC007594, BC080183, BX460002
      Consensus CDS
      CCDS42177.1
      UniProtKB/Swiss-Prot
      A2VCS8, Q68EN5, Q8N3H9, Q8NAQ5, Q96IE5
      Related
      ENSP00000456838.1, ENST00000563902.2
      Conserved Domains (1) summary
      cl06858
      Location:237 → 445
      DUF1704; Domain of unknown function (DUF1704)

    2. NM_001369680.1 → NP_001356609.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC074143
      Consensus CDS
      CCDS42177.1
      UniProtKB/Swiss-Prot
      A2VCS8, Q68EN5, Q8N3H9, Q8NAQ5, Q96IE5
      Related
      ENSP00000290881.7, ENST00000290881.11
      Conserved Domains (1) summary
      cl06858
      Location:237 → 445
      DUF1704; Domain of unknown function (DUF1704)

    3. NM_001369681.1 → NP_001356610.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC074143
      Consensus CDS
      CCDS42177.1
      UniProtKB/Swiss-Prot
      A2VCS8, Q68EN5, Q8N3H9, Q8NAQ5, Q96IE5
      Conserved Domains (1) summary
      cl06858
      Location:237 → 445
      DUF1704; Domain of unknown function (DUF1704)

    4. NM_001369682.1 → NP_001356611.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC074143
      Consensus CDS
      CCDS42177.1
      UniProtKB/Swiss-Prot
      A2VCS8, Q68EN5, Q8N3H9, Q8NAQ5, Q96IE5
      Conserved Domains (1) summary
      cl06858
      Location:237 → 445
      DUF1704; Domain of unknown function (DUF1704)

    5. NM_001369684.1 → NP_001356613.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC074143
      Consensus CDS
      CCDS42177.1
      UniProtKB/Swiss-Prot
      A2VCS8, Q68EN5, Q8N3H9, Q8NAQ5, Q96IE5
      Conserved Domains (1) summary
      cl06858
      Location:237 → 445
      DUF1704; Domain of unknown function (DUF1704)

    6. NM_001369685.1 → NP_001356614.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC074143
      Consensus CDS
      CCDS42177.1
      UniProtKB/Swiss-Prot
      A2VCS8, Q68EN5, Q8N3H9, Q8NAQ5, Q96IE5
      Conserved Domains (1) summary
      cl06858
      Location:237 → 445
      DUF1704; Domain of unknown function (DUF1704)

    7. NM_001369686.1 → NP_001356615.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC074143
      Consensus CDS
      CCDS42177.1
      UniProtKB/Swiss-Prot
      A2VCS8, Q68EN5, Q8N3H9, Q8NAQ5, Q96IE5
      Conserved Domains (1) summary
      cl06858
      Location:237 → 445
      DUF1704; Domain of unknown function (DUF1704)

    8. NM_001369687.1 → NP_001356616.1  microtubule-associated tyrosine carboxypeptidase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC074143
      Consensus CDS
      CCDS92174.1
      Related
      ENSP00000457099.1, ENST00000561621.5
      Conserved Domains (1) summary
      cl06858
      Location:144 → 377
      DUF1704; Domain of unknown function (DUF1704)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67175599..67183963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      72969893..72978247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68EN5.1 GenPept UniProtKB/Swiss-Prot:Q68EN5

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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