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    ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 [ Homo sapiens (human) ]

    Gene ID: 955, updated on 27-Nov-2024

    Summary

    Official Symbol
    ENTPD6provided by HGNC
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 6provided by HGNC
    Primary source
    HGNC:HGNC:3368
    See related
    Ensembl:ENSG00000197586 MIM:603160; AllianceGenome:HGNC:3368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD39L2; IL6ST2; IL-6SAG; NTPDase-6; dJ738P15.3
    Summary
    ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in prostate (RPKM 15.7), colon (RPKM 15.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ENTPD6 in Genome Data Viewer
    Location:
    20p11.21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (25195712..25228075)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (25260296..25293060)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (25176348..25208711)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC284798 Neighboring gene Sharpr-MPRA regulatory region 10160 Neighboring gene NIPAL1 pseudogene 1 Neighboring gene uncharacterized LOC101926889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17662 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17663 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:25194425-25194926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:25202205-25202966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:25202967-25203726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:25203727-25204488 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:25204539-25204720 Neighboring gene uncharacterized LOC105372579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17664 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12742 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:25218064-25219263 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:25222455-25223072 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:25227753-25228006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17665 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12746 Neighboring gene glycogen phosphorylase B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:25274716-25275238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:25276284-25276805 Neighboring gene abhydrolase domain containing 12, lysophospholipase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ36711, dJ738P15.3,, DKFZp781G2277, DKFZp781K21102

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to magnesium ion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 6
    Names
    CD39 antigen-like 2
    NTPDase 6
    ectonucleoside triphosphate diphosphohydrolase 6 (putative)
    interleukin 6 signal transducer-2
    NP_001107561.2
    NP_001238.3
    NP_001304870.2
    NP_001309307.2
    NP_001309308.1
    NP_001309309.1
    NP_001309310.1
    NP_001309311.1
    NP_001309312.1
    NP_001309313.1
    NP_001309314.2
    NP_001309315.2
    NP_001309316.2
    NP_001309317.2
    NP_001309318.2
    NP_001309319.2
    NP_001309320.2
    NP_001309321.2
    NP_001309322.2
    NP_001309323.2
    NP_001309324.2
    NP_001309325.2
    NP_001309326.2
    NP_001309327.2
    XP_016883622.1
    XP_016883623.1
    XP_047296547.1
    XP_047296548.1
    XP_047296549.1
    XP_047296550.1
    XP_047296551.1
    XP_047296552.1
    XP_047296553.1
    XP_047296554.1
    XP_047296555.1
    XP_047296556.1
    XP_054180205.1
    XP_054180206.1
    XP_054180207.1
    XP_054180208.1
    XP_054180209.1
    XP_054180210.1
    XP_054180211.1
    XP_054180212.1
    XP_054180213.1
    XP_054180214.1
    XP_054180215.1
    XP_054180216.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114089.4NP_001107561.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' region, resulting in a distinct 5' UTR and the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus, and is shorter than isoform 1.
      Source sequence(s)
      AL035252
      Consensus CDS
      CCDS46586.1
      UniProtKB/TrEMBL
      B4E1D1
      Related
      ENSP00000347084.5, ENST00000354989.9
      Conserved Domains (1) summary
      cl17037
      Location:78460
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. NM_001247.5NP_001238.3  ectonucleoside triphosphate diphosphohydrolase 6 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL035252
      Consensus CDS
      CCDS13170.1
      UniProtKB/Swiss-Prot
      A6NCX6, D3DW49, O75354, Q5QPJ2, Q5QPJ5, Q7Z5B5, Q8N3H3, Q8TAS7, Q9UJD1
      UniProtKB/TrEMBL
      B4E1D1
      Related
      ENSP00000365840.4, ENST00000376652.9
      Conserved Domains (1) summary
      cl17037
      Location:95477
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    3. NM_001317941.3NP_001304870.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AL035252
      Consensus CDS
      CCDS82604.1
      UniProtKB/TrEMBL
      B4E1D1
      Related
      ENSP00000353131.2, ENST00000360031.6
      Conserved Domains (1) summary
      cl17037
      Location:94476
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    4. NM_001322378.2NP_001309307.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL035252
      Consensus CDS
      CCDS13170.1
      UniProtKB/Swiss-Prot
      A6NCX6, D3DW49, O75354, Q5QPJ2, Q5QPJ5, Q7Z5B5, Q8N3H3, Q8TAS7, Q9UJD1
      UniProtKB/TrEMBL
      B4E1D1
      Conserved Domains (1) summary
      cl17037
      Location:95477
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    5. NM_001322379.2NP_001309308.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4DHS2, B4DU64
      Conserved Domains (1) summary
      cl17037
      Location:1225
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    6. NM_001322380.2NP_001309309.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      H0Y3D0
      Conserved Domains (1) summary
      cl17037
      Location:1178
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    7. NM_001322381.2NP_001309310.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      H0Y3D0
      Conserved Domains (1) summary
      cl17037
      Location:1178
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    8. NM_001322382.2NP_001309311.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4DU64
      Conserved Domains (1) summary
      cl17037
      Location:1259
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    9. NM_001322383.2NP_001309312.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4DU64
      Conserved Domains (1) summary
      cl17037
      Location:1259
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    10. NM_001322384.2NP_001309313.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4DU64
      Conserved Domains (1) summary
      cl17037
      Location:1259
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    11. NM_001322385.2NP_001309314.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4E1D1
      Conserved Domains (1) summary
      cl17037
      Location:78412
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    12. NM_001322386.2NP_001309315.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4E1D1
      Conserved Domains (1) summary
      cl17037
      Location:78426
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    13. NM_001322387.2NP_001309316.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4E1D1
      Conserved Domains (1) summary
      cl17037
      Location:95429
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    14. NM_001322388.2NP_001309317.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL035252
      Consensus CDS
      CCDS82603.1
      UniProtKB/TrEMBL
      B4DNK6, Q5QPI9
      Related
      ENSP00000401895.2, ENST00000433259.6
      Conserved Domains (1) summary
      cl17037
      Location:95303
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    15. NM_001322389.2NP_001309318.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4E1D1
      Conserved Domains (1) summary
      cl17037
      Location:92440
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    16. NM_001322390.2NP_001309319.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4E1D1
      Conserved Domains (1) summary
      cl17037
      Location:95443
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    17. NM_001322391.2NP_001309320.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4E1D1
      Conserved Domains (1) summary
      cl17037
      Location:95443
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    18. NM_001322392.2NP_001309321.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4DDM7
      Conserved Domains (1) summary
      cl17037
      Location:77378
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    19. NM_001322393.2NP_001309322.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4DDM7
      Conserved Domains (1) summary
      cl17037
      Location:78379
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    20. NM_001322394.2NP_001309323.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4E1D1
      Conserved Domains (1) summary
      cl17037
      Location:77459
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    21. NM_001322395.2NP_001309324.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4DDM7
      Conserved Domains (1) summary
      cl17037
      Location:92393
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    22. NM_001322396.2NP_001309325.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4DNK6
      Conserved Domains (1) summary
      cl17037
      Location:94395
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    23. NM_001322397.2NP_001309326.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4DNK6
      Conserved Domains (1) summary
      cl17037
      Location:95396
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    24. NM_001322398.2NP_001309327.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL035252
      UniProtKB/TrEMBL
      B4E1D1
      Conserved Domains (1) summary
      cl17037
      Location:92474
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      25195712..25228075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440595.1XP_047296551.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X4

      Conserved Domains (1) summary
      cl17037
      Location:92393
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. XM_047440594.1XP_047296550.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X3

    3. XM_047440597.1XP_047296553.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X6

    4. XM_047440596.1XP_047296552.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X5

      Conserved Domains (1) summary
      cl17037
      Location:92440
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    5. XM_047440598.1XP_047296554.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X7

    6. XM_017028133.3XP_016883622.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X8

      UniProtKB/TrEMBL
      B4DDM7
    7. XM_017028134.2XP_016883623.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X11

    8. XM_047440599.1XP_047296555.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X9

    9. XM_047440591.1XP_047296547.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X1

      UniProtKB/Swiss-Prot
      A6NCX6, D3DW49, O75354, Q5QPJ2, Q5QPJ5, Q7Z5B5, Q8N3H3, Q8TAS7, Q9UJD1
    10. XM_047440592.1XP_047296548.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X2

    11. XM_047440593.1XP_047296549.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X2

    12. XM_047440600.1XP_047296556.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X10

      Related
      ENSP00000365854.3, ENST00000376666.3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      25260296..25293060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324234.1XP_054180209.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X4

    2. XM_054324233.1XP_054180208.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X3

    3. XM_054324236.1XP_054180211.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X6

    4. XM_054324235.1XP_054180210.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X5

    5. XM_054324237.1XP_054180212.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X7

    6. XM_054324238.1XP_054180213.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X8

    7. XM_054324241.1XP_054180216.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X11

    8. XM_054324239.1XP_054180214.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X9

    9. XM_054324230.1XP_054180205.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X1

    10. XM_054324231.1XP_054180206.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X2

    11. XM_054324232.1XP_054180207.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X2

    12. XM_054324240.1XP_054180215.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X10