STK4 serine/threonine kinase 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STK4provided by HGNC
Official Full Name: serine/threonine kinase 4provided by HGNC
Primary source: HGNC:HGNC:11408
See related: Ensembl:ENSG00000101109 MIM:604965; AllianceGenome:HGNC:11408
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KRS2; MST1; YSK3
Summary: The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
Annotation information: Note: MST1 (Gene ID: 4485) and STK4 (Gene ID: 6789) share the MST1 symbol/alias in common. MST1 is a widely used alternative name for serine/threonine kinase 4 (STK4), which can be confused with the official symbol for macrophage stimulating 1 (MST1). [01 Jun 2018]
Expression: Broad expression in lymph node (RPKM 17.1), appendix (RPKM 14.6) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (44966512..45080021)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (46702402..46815925)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (43595153..43708662)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association Study between SNPs in MST1 and MST2 and H. pylori Infection as well as Noncardia Gastric Carcinogenesis.
Title: Association Study between SNPs in MST1 and MST2 and H. pylori Infection as well as Noncardia Gastric Carcinogenesis.
MST1 knockdown inhibits osteoarthritis progression through Parkin-mediated mitophagy and Nrf2/NF-kappaB signalling pathway.
Title: MST1 knockdown inhibits osteoarthritis progression through Parkin-mediated mitophagy and Nrf2/NF-κB signalling pathway.
The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress.
Title: The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress.
Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions.
Title: Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions.
STK4 is a prognostic biomarker correlated with immune infiltrates in clear cell renal cell carcinoma.
Title: STK4 is a prognostic biomarker correlated with immune infiltrates in clear cell renal cell carcinoma.
MST1 downregulates TAZ tumor suppressor protein in multiple myeloma and is a potential therapeutic target.
Title: MST1 downregulates TAZ tumor suppressor protein in multiple myeloma and is a potential therapeutic target.
Hematopoietic stem cell transplantation in serine/threonine kinase 4 (STK4) deficiency: Report of two cases and literature review.
Title: Hematopoietic stem cell transplantation in serine/threonine kinase 4 (STK4) deficiency: Report of two cases and literature review.
Mammalian STE20-like kinase-1/2 are activated in human platelets stimulated by collagen or thrombin and play a vital role in collagen-activated platelets.
Title: Mammalian STE20-like kinase-1/2 are activated in human platelets stimulated by collagen or thrombin and play a vital role in collagen-activated platelets.
Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington's Disease and Other Neurodegenerative Disorders.
Title: Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington's Disease and Other Neurodegenerative Disorders.
LncRNA GAS5 enhances tumor stem cell-like medicated sensitivity of paclitaxel and inhibits epithelial-to-mesenchymal transition by targeting the miR-18a-5p/STK4 pathway in prostate cancer.
Title: LncRNA GAS5 enhances tumor stem cell-like medicated sensitivity of paclitaxel and inhibits epithelial-to-mesenchymal transition by targeting the miR-18a-5p/STK4 pathway in prostate cancer.

Submit: New GeneRIF Correction See all GeneRIFs (116)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Combined immunodeficiency due to STK4 deficiency MedGen: C3553943 OMIM: 614868 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Z94383 (e-PCR)
- UniSTS:80135

D20S119 (e-PCR), detects polymorphism
- UniSTS:37902

D20S119 (e-PCR), detects polymorphism
- UniSTS:3353

RH18007 (e-PCR)
- UniSTS:34846

D20S1069 (e-PCR)
- UniSTS:29490

D8S2279 (e-PCR)
- UniSTS:473907

RH66078 (e-PCR)
- UniSTS:9534

NoName (e-PCR)
- UniSTS:483393

GDB:314949 (e-PCR)
- UniSTS:156503

L18426 (e-PCR)
- UniSTS:34648

D17S1239 (e-PCR)
- UniSTS:149852

G38154 (e-PCR)
- UniSTS:53341

D1S1425 (e-PCR)
- UniSTS:149621

G35510 (e-PCR)
- UniSTS:44150

RH47839 (e-PCR)
- UniSTS:15494

AL022266 (e-PCR)
- UniSTS:75419

RH68914 (e-PCR)
- UniSTS:31144

AL023484 (e-PCR)
- UniSTS:50097

Z94386 (e-PCR)
- UniSTS:8125

SHGC-106156 (e-PCR)
- UniSTS:169664

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	TAS Traceable Author Statement more info	PubMed
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in branching involved in blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation involved in embryonic placenta development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system development	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in endocardium development	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in hippo signaling	TAS Traceable Author Statement more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of organ growth	IEA Inferred from Electronic Annotation more info
involved_in neural tube formation	IEA Inferred from Electronic Annotation more info
involved_in organ growth	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of hippo signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate	IEA Inferred from Electronic Annotation more info
involved_in primitive hemopoiesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein tetramerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell differentiation involved in embryonic placenta development	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase 4

Names: STE20-like kinase MST1; hippo homolog; kinase responsive to stress 2; mammalian STE20-like protein kinase 1; mammalian sterile 20-like 1; serine/threonine-protein kinase Krs-2

NP_001339314.1

EC 2.7.11.1

NP_006273.1

EC 2.7.11.1

XP_005260589.1

EC 2.7.11.1

XP_011527320.1

EC 2.7.11.1

XP_016883520.1

EC 2.7.11.1

XP_016883522.1

EC 2.7.11.1

XP_047296381.1

EC 2.7.11.1

XP_047296382.1

EC 2.7.11.1

XP_054179906.1

EC 2.7.11.1

XP_054179907.1

EC 2.7.11.1

XP_054179908.1

EC 2.7.11.1

XP_054179909.1

EC 2.7.11.1

XP_054179910.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032172.1 RefSeqGene

Range

5001..118475

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_535

mRNA and Protein(s)

NM_001352385.2 → NP_001339314.1 serine/threonine-protein kinase 4 isoform 2

Status: REVIEWED

Source sequence(s)

AK027088, AL109839, BC038850, Z93016

Consensus CDS

CCDS86957.1

UniProtKB/TrEMBL

A0PJ51

Related

ENSP00000361887.1, ENST00000372801.5

Conserved Domains (1) summary

cd06612
Location:26 → 281

STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
NM_006282.5 → NP_006273.1 serine/threonine-protein kinase 4 isoform 1

See identical proteins and their annotated locations for NP_006273.1

Status: REVIEWED

Source sequence(s)

AK027088, AL597960, U60207, Z93016

Consensus CDS

CCDS13341.1

UniProtKB/Swiss-Prot

B2RCR8, Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4

UniProtKB/TrEMBL

Q59FZ4

Related

ENSP00000361892.3, ENST00000372806.8

Conserved Domains (3) summary

cd06612
Location:26 → 281

STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

smart00220
Location:30 → 281

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam11629
Location:433 → 480

Mst1_SARAH; C terminal SARAH domain of Mst1

RNA

NR_147974.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL109839, BC039023

Related

ENST00000487587.3
NR_147975.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL109839

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

44966512..45080021

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017028031.3 → XP_016883520.1 serine/threonine-protein kinase 4 isoform X1

UniProtKB/TrEMBL

Q59FZ4

Conserved Domains (3) summary

cd06612
Location:17 → 268

STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

smart00220
Location:24 → 268

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam11629
Location:420 → 467

Mst1_SARAH; C terminal SARAH domain of Mst1
XM_011529018.4 → XP_011527320.1 serine/threonine-protein kinase 4 isoform X3

See identical proteins and their annotated locations for XP_011527320.1

UniProtKB/TrEMBL

A0A087WVN8, Q59FZ4

Related

ENSP00000479564.2, ENST00000474717.3

Conserved Domains (3) summary

cd06612
Location:1 → 205

STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

smart00220
Location:1 → 205

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam11629
Location:357 → 404

Mst1_SARAH; C terminal SARAH domain of Mst1
XM_047440425.1 → XP_047296381.1 serine/threonine-protein kinase 4 isoform X1
XM_005260532.5 → XP_005260589.1 serine/threonine-protein kinase 4 isoform X1

UniProtKB/TrEMBL

Q59FZ4

Conserved Domains (3) summary

cd06612
Location:17 → 268

STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2

smart00220
Location:24 → 268

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam11629
Location:420 → 467

Mst1_SARAH; C terminal SARAH domain of Mst1
XM_017028033.2 → XP_016883522.1 serine/threonine-protein kinase 4 isoform X4

UniProtKB/TrEMBL

A0PJ51
XM_047440426.1 → XP_047296382.1 serine/threonine-protein kinase 4 isoform X2