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    UBE2C ubiquitin conjugating enzyme E2 C [ Homo sapiens (human) ]

    Gene ID: 11065, updated on 27-Nov-2024

    Summary

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    Official Symbol
    UBE2Cprovided by HGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 Cprovided by HGNC
    Primary source
    HGNC:HGNC:15937
    See related
    Ensembl:ENSG00000175063 MIM:605574; AllianceGenome:HGNC:15937
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBCH10; dJ447F3.2
    Summary
    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]
    Expression
    Biased expression in bone marrow (RPKM 14.3), lymph node (RPKM 11.0) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See UBE2C in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (45812644..45816952)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (47549141..47553438)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44441283..44445591)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, U6atac small nuclear 38, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44408579-44409079 Neighboring gene Sharpr-MPRA regulatory region 6194 Neighboring gene WAP four-disulfide core domain 3 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_60411 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12960 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12961 Neighboring gene deoxynucleotidyltransferase terminal interacting protein 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_60428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12962 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:44447254-44447902 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:44449199-44449846 Neighboring gene troponin C2, fast skeletal type Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12963 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44468841-44469394 Neighboring gene sorting nexin family member 21 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44470503-44471055 Neighboring gene acyl-CoA thioesterase 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The clinical significance of UBE2C gene in progression of renal cell carcinoma. Chen Z, et al. Eur J Histochem, 2021 Mar 29. PMID 33782624, Free PMC Article
    2. [UbcH10 expression in hepatocellular carcinoma and its clinicopathological significance]. Han SS, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2011 Feb. PMID 21354912
    3. [Effect of UBE2C overexpression on the proliferation of 293T cell line]. Huang X, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2011 Jun. PMID 21651863
    4. Prognostic significance of UBE2C mRNA expression in high-risk early breast cancer. A Hellenic Cooperative Oncology Group (HeCOG) Study. Psyrri A, et al. Ann Oncol, 2012 Jun. PMID 22056852
    5. UbcH10 expression in benign, hyperplastic, and malignant endometrial curetted materials: a tissue microarray study. Kefeli M, et al. Int J Surg Pathol, 2012 Aug. PMID 22415060

    See all (258) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UBE2C regulates the KEAP1/NRF2 signaling pathway to promote the growth of gastric cancer by inhibiting autophagy.
      Title: UBE2C regulates the KEAP1/NRF2 signaling pathway to promote the growth of gastric cancer by inhibiting autophagy.
    2. UBE2C-induced crosstalk between mono- and polyubiquitination of SNAT2 promotes lymphatic metastasis in bladder cancer.
      Title: UBE2C-induced crosstalk between mono- and polyubiquitination of SNAT2 promotes lymphatic metastasis in bladder cancer.
    3. UBE2C promotes the proliferation of acute myeloid leukemia cells through PI3K/AKT activation.
      Title: UBE2C promotes the proliferation of acute myeloid leukemia cells through PI3K/AKT activation.
    4. UBE2C promotes malignancy of cutaneous squamous cell carcinoma.
      Title: UBE2C promotes malignancy of cutaneous squamous cell carcinoma.
    5. Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma.
      Title: Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma.
    6. Role of UBE2C in Brain Cancer Invasion and Dissemination.
      Title: Role of UBE2C in Brain Cancer Invasion and Dissemination.
    7. Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency.
      Title: Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency.
    8. Comprehensive analysis of UBE2C expression and its potential roles and mechanisms in hepatocellular carcinoma.
      Title: Comprehensive analysis of UBE2C expression and its potential roles and mechanisms in hepatocellular carcinoma.
    9. Restored UBE2C expression in islets promotes beta-cell regeneration in mice by ubiquitinating PER1.
      Title: Restored UBE2C expression in islets promotes β-cell regeneration in mice by ubiquitinating PER1.
    10. System analysis identifies UBE2C as a novel oncogene target for adrenocortical carcinoma.
      Title: System analysis identifies UBE2C as a novel oncogene target for adrenocortical carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (103)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of ubiquitin-conjugating enzyme E2C (UBE2C) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity TAS
    Traceable Author Statement
    more info
    		  
    enables ubiquitin-like protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in free ubiquitin chain polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic metaphase/anaphase transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ubiquitin protein ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 C
    Names
    (E3-independent) E2 ubiquitin-conjugating enzyme C
    E2 ubiquitin-conjugating enzyme C
    cyclin-selective ubiquitin carrier protein
    mitotic-specific ubiquitin-conjugating enzyme
    ubiquitin conjugating enzyme E2C
    ubiquitin-protein ligase C
    NP_001268670.1
    NP_001268671.1
    NP_008950.1
    NP_861515.1
    NP_861516.1
    NP_861517.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281741.2 → NP_001268670.1  ubiquitin-conjugating enzyme E2 C isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has multiple differences in the central coding region but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter, compared to isoform 1.
      Source sequence(s)
      BU171488
      Consensus CDS
      CCDS74734.1
      UniProtKB/TrEMBL
      A0A087WVK1
      Related
      ENSP00000479486.1, ENST00000617055.4
      Conserved Domains (1) summary
      cl00154
      Location:92 → 123
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_001281742.2 → NP_001268671.1  ubiquitin-conjugating enzyme E2 C isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an exon in central coding region, which results in a translational frameshift, compared to variant 1. The encoded isoform (7) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      CN354813, DB062573
      Consensus CDS
      CCDS74733.1
      UniProtKB/TrEMBL
      A0A0A0MSE8
      Related
      ENSP00000385878.2, ENST00000405520.5
      Conserved Domains (1) summary
      cl00154
      Location:33 → 72
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_007019.4 → NP_008950.1  ubiquitin-conjugating enzyme E2 C isoform 1

      See identical proteins and their annotated locations for NP_008950.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC007656, DB062573
      Consensus CDS
      CCDS13370.1
      UniProtKB/Swiss-Prot
      A6NP33, E1P5N7, G3XAB7, O00762
      UniProtKB/TrEMBL
      B2R4U3, Q5TZN3
      Related
      ENSP00000348838.4, ENST00000356455.9
      Conserved Domains (1) summary
      pfam00179
      Location:34 → 170
      UQ_con; Ubiquitin-conjugating enzyme

    4. NM_181799.3 → NP_861515.1  ubiquitin-conjugating enzyme E2 C isoform 2

      See identical proteins and their annotated locations for NP_861515.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      BC007656, BU169315, DB062573
      Consensus CDS
      CCDS13371.1
      UniProtKB/Swiss-Prot
      O00762
      Related
      ENSP00000335674.3, ENST00000335046.7
      Conserved Domains (1) summary
      cl00154
      Location:33 → 152
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    5. NM_181800.3 → NP_861516.1  ubiquitin-conjugating enzyme E2 C isoform 3

      See identical proteins and their annotated locations for NP_861516.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      BC007656, CK904708, DB062573
      Consensus CDS
      CCDS13372.1
      UniProtKB/TrEMBL
      B2R4U3
      Related
      ENSP00000333975.5, ENST00000352551.9
      Conserved Domains (1) summary
      pfam00179
      Location:44 → 141
      UQ_con; Ubiquitin-conjugating enzyme

    6. NM_181801.4 → NP_861517.1  ubiquitin-conjugating enzyme E2 C isoform 4

      See identical proteins and their annotated locations for NP_861517.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5'-terminal exon and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL050348, BC007656, BI858659, BP227692
      Consensus CDS
      CCDS13374.1
      UniProtKB/Swiss-Prot
      O00762
      Related
      ENSP00000361649.4, ENST00000372568.4
      Conserved Domains (1) summary
      pfam00179
      Location:1 → 131
      UQ_con; Ubiquitin-conjugating enzyme

    RNA

    1. NR_104036.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two internal exons, as compared to variant 1. This variant is represented as non-coding because it lacks a significant portion of the coding region and does not encode a supported protein.
      Source sequence(s)
      BC007656, CB143441, DB062573
      Related
      ENST00000243893.10

    2. NR_104037.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses two alternate splice sites in internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC007656, CN354815, DB062573

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      45812644..45816952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      47549141..47553438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181802.1: Suppressed sequence

      Description
      NM_181802.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

    2. NM_181803.1: Suppressed sequence

      Description
      NM_181803.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00762.1 GenPept UniProtKB/Swiss-Prot:O00762

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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