Mtnr1a melatonin receptor 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtnr1aprovided by MGI
Official Full Name: melatonin receptor 1Aprovided by MGI
Primary source: MGI:MGI:102967
See related: Ensembl:ENSMUSG00000054764 AllianceGenome:MGI:102967
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MR; MelR
Summary: Predicted to enable hormone binding activity; melatonin receptor activity; and organic cyclic compound binding activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and negative regulation of insulin secretion. Predicted to act upstream of or within circadian rhythm. Predicted to be located in neuronal cell body. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; liver and biliary system; and reproductive system. Orthologous to human MTNR1A (melatonin receptor 1A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 1.3), liver adult (RPKM 0.1) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B1.1; 8 24.95 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (45522144..45542270)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (45069107..45089233)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Melatonin receptor 1A variants as genetic cause of idiopathic osteoporosis.
Title: Melatonin receptor 1A variants as genetic cause of idiopathic osteoporosis.
The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
Title: The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
Changes in melatonin receptor expression in a murine model of glaucoma.
Title: Changes in melatonin receptor expression in a murine model of glaucoma.
found in The organ of Corti, spiral ganglion, vestibular ganglion, vestibular sensory cells, vestibular dark and transitional cells, and endolymphatic sac epithelial cells
Title: Localization of melatonin and its receptors (melatonin 1a and 1b receptors) in the mouse inner ear.
MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations.
Title: MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations.
study presents the first direct evidence that the MT2 subtype, but not MT1, is a novel endogenous cardiac protective receptor against MI/R injury. Medications specifically targeting MT2 may hold promise in fighting ischemic heart disease.
Title: Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin-conferred cardioprotection against myocardial ischemia/reperfusion injury.
MT1/MT2 receptors activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway.
Title: Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway.
These results suggested that the melatonin receptors MTNR1A and MTNR1B are essential to repress hCG-induced endoplasmic reticulum stress and cell apoptosis.
Title: Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells.
Melatonin MT1 and MT2 receptors interact with dopamine transporter (DAT) in striatum.
Title: Melatonin receptors limit dopamine reuptake by regulating dopamine transporter cell-surface exposure.
our data demonstrate that the activation of MT1 signaling at night modulates insulin sensitivity during the day via the regulation of the PI3K transcription and activity
Title: Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (3) 1 citation

General gene information

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Markers

Mtnr1a (e-PCR), detects polymorphism
- UniSTS:143930

Mtnr1a (e-PCR), detects polymorphism
- UniSTS:143931

U52222 (e-PCR)
- UniSTS:163435

NoName (e-PCR)
- UniSTS:491257

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone binding	IEA Inferred from Electronic Annotation more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables melatonin receptor activity	ISO Inferred from Sequence Orthology more info
enables melatonin receptor activity	TAS Traceable Author Statement more info	PubMed
enables organic cyclic compound binding	IEA Inferred from Electronic Annotation more info
enables organic cyclic compound binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within circadian rhythm	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: melatonin receptor type 1A

Names: Mel1a receptor; mel-1A-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008639.3 → NP_032665.1 melatonin receptor type 1A

See identical proteins and their annotated locations for NP_032665.1

Status: VALIDATED

Source sequence(s)

AC158352

Consensus CDS

CCDS22273.1

UniProtKB/Swiss-Prot

Q61184

UniProtKB/TrEMBL

Q14AC3

Related

ENSMUSP00000069872.8, ENSMUST00000067984.9

Conserved Domains (2) summary

pfam00001
Location:47 → 298

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:38 → 160

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

45522144..45542270

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509292.2 → XP_006509355.2 melatonin receptor type 1A isoform X1

Conserved Domains (2) summary

cd14964
Location:31 → 56

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:27 → 275

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_017312597.1 → XP_017168086.1 melatonin receptor type 1A isoform X2

Conserved Domains (2) summary

cd14964
Location:30 → 55

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:26 → 274

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_011242176.1 → XP_011240478.1 melatonin receptor type 1A isoform X4

Conserved Domains (2) summary

cd14964
Location:3 → 28

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:3 → 247

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006509291.3 → XP_006509354.1 melatonin receptor type 1A isoform X3

Conserved Domains (2) summary

cd14964
Location:3 → 28

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:3 → 247

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily