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    Actr6 ARP6 actin-related protein 6 [ Mus musculus (house mouse) ]

    Gene ID: 67019, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Actr6provided by MGI
    Official Full Name
    ARP6 actin-related protein 6provided by MGI
    Primary source
    MGI:MGI:1914269
    See related
    Ensembl:ENSMUSG00000019948 AllianceGenome:MGI:1914269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arp6; ArpX; CDA12; 2010200J04Rik
    Summary
    Predicted to enable nucleosome binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase I; nucleolus organization; and positive regulation of transcription by RNA polymerase I. Predicted to be located in nucleolus. Predicted to be part of Swr1 complex. Is expressed in ovary. Orthologous to human ACTR6 (actin related protein 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 7.5), CNS E14 (RPKM 6.0) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Actr6 in Genome Data Viewer
    Location:
    10 C2; 10 45.14 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (89547828..89568184, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (89711966..89732319, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene SCY1-like 2 (S. cerevisiae) Neighboring gene RIKEN cDNA 1500026H17 gene Neighboring gene STARR-positive B cell enhancer ABC_E5164 Neighboring gene STARR-seq mESC enhancer starr_27523 Neighboring gene STARR-positive B cell enhancer ABC_E2334 Neighboring gene STARR-positive B cell enhancer ABC_E6899 Neighboring gene predicted gene, 30963 Neighboring gene bridge-like lipid transfer protein family member 3B Neighboring gene predicted gene, 31090

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. Ruhl DD, et al. Biochemistry, 2006 May 2. PMID 16634648
    2. Molecular evolution of the actin family. Goodson HV, et al. J Cell Sci, 2002 Jul 1. PMID 12077353
    3. Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. Munger SC, et al. Genes Dev, 2009 Nov 1. PMID 19884258, Free PMC Article
    4. Network organization of the huntingtin proteomic interactome in mammalian brain. Shirasaki DI, et al. Neuron, 2012 Jul 12. PMID 22794259, Free PMC Article
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nucleolus organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleolus organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Swr1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of nucleosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    actin-related protein 6
    Names
    ARP6 actin-related protein 6 homolog
    mArp6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359468.2 → NP_001346397.1  actin-related protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130216
      Conserved Domains (1) summary
      smart00268
      Location:1 → 286
      ACTIN; Actin

    2. NM_001359469.1 → NP_001346398.1  actin-related protein 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC130216, AK008409, CJ221252
      Conserved Domains (1) summary
      cl17037
      Location:1 → 199
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. NM_001429398.1 → NP_001416327.1  actin-related protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130216

    4. NM_001429399.1 → NP_001416328.1  actin-related protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130216

    5. NM_001429400.1 → NP_001416329.1  actin-related protein 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC130216

    6. NM_001429401.1 → NP_001416330.1  actin-related protein 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC130216

    7. NM_001429402.1 → NP_001416331.1  actin-related protein 6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC130216

    8. NM_001429403.1 → NP_001416332.1  actin-related protein 6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC130216

    9. NM_025914.3 → NP_080190.1  actin-related protein 6 isoform 1

      See identical proteins and their annotated locations for NP_080190.1

      Status: VALIDATED

      Source sequence(s)
      AK008409, CJ221252
      Consensus CDS
      CCDS24118.1
      UniProtKB/TrEMBL
      A0A0R4J009
      Related
      ENSMUSP00000020109.4, ENSMUST00000020109.5
      Conserved Domains (2) summary
      smart00268
      Location:2 → 394
      ACTIN; Actin
      COG5277
      Location:2 → 393
      COG5277; Actin-related protein [Cytoskeleton]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      89547828..89568184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513965.3 → XP_006514028.1  actin-related protein 6 isoform X1

      Conserved Domains (1) summary
      smart00268
      Location:10 → 312
      ACTIN; Actin

    2. XM_006513966.4 → XP_006514029.1  actin-related protein 6 isoform X1

      Conserved Domains (1) summary
      smart00268
      Location:10 → 312
      ACTIN; Actin

    3. XM_011243532.3 → XP_011241834.1  actin-related protein 6 isoform X2

      Conserved Domains (1) summary
      smart00268
      Location:1 → 286
      ACTIN; Actin

    4. XM_006513967.4 → XP_006514030.1  actin-related protein 6 isoform X3

      Conserved Domains (1) summary
      cl17037
      Location:1 → 199
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    5. XM_030245223.1 → XP_030101083.1  actin-related protein 6 isoform X2

      Conserved Domains (1) summary
      smart00268
      Location:1 → 286
      ACTIN; Actin

    6. XM_036155958.1 → XP_036011851.1  actin-related protein 6 isoform X3

      Conserved Domains (1) summary
      cl17037
      Location:1 → 199
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    7. XM_030245224.1 → XP_030101084.1  actin-related protein 6 isoform X3

      Conserved Domains (1) summary
      cl17037
      Location:1 → 199
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D864.2 GenPept UniProtKB/Swiss-Prot:Q9D864

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