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    Camta2 calmodulin binding transcription activator 2 [ Mus musculus (house mouse) ]

    Gene ID: 216874, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Camta2provided by MGI
    Official Full Name
    calmodulin binding transcription activator 2provided by MGI
    Primary source
    MGI:MGI:2135957
    See related
    Ensembl:ENSMUSG00000040712 AllianceGenome:MGI:2135957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0909; Kiaa0909-hp
    Summary
    Enables sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including brain; eye; foregut; male reproductive gland or organ; and urinary system. Orthologous to human CAMTA2 (calmodulin binding transcription activator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 27.2), duodenum adult (RPKM 25.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Camta2 in Genome Data Viewer
    Location:
    11 B3; 11 43.21 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70560288..70578966, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70669463..70688145, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3969 Neighboring gene profilin 1 Neighboring gene enolase 3, beta muscle Neighboring gene STARR-positive B cell enhancer ABC_E62 Neighboring gene sperm associated antigen 7 Neighboring gene inhibitor of CDK, cyclin A1 interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7009 Neighboring gene kinesin family member 1C Neighboring gene microRNA 6925

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor. Long C, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049392, Free PMC Article
    2. The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases. Song K, et al. Cell, 2006 May 5. PMID 16678093
    3. Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling. Darlington TM, et al. Genes Brain Behav, 2016 Jun. PMID 27063791, Free PMC Article
    4. Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11. Watters JW, et al. Genomics, 2001 Apr 15. PMID 11318612
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin-binding transcription activator 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190376.1 → NP_001177305.1  calmodulin-binding transcription activator 2 isoform 2

      See identical proteins and their annotated locations for NP_001177305.1

      Status: VALIDATED

      Source sequence(s)
      AK169118, AL596117, BB856280, BC056395
      Consensus CDS
      CCDS56788.1
      UniProtKB/Swiss-Prot
      Q80Y50
      Related
      ENSMUSP00000104184.2, ENSMUST00000108544.8
      Conserved Domains (5) summary
      smart01076
      Location:34 → 150
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00204
      Location:713 → 811
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01833
      Location:537 → 616
      TIG; IPT/TIG domain
      pfam13637
      Location:713 → 777
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:712 → 755
      ANK; ANK repeat [structural motif]

    2. NM_001190378.1 → NP_001177307.1  calmodulin-binding transcription activator 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596117
      Consensus CDS
      CCDS56787.1
      UniProtKB/TrEMBL
      B0QZH4
      Related
      ENSMUSP00000113847.2, ENSMUST00000119120.2
      Conserved Domains (4) summary
      smart01076
      Location:34 → 150
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      sd00045
      Location:712 → 755
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:537 → 616
      TIG; IPT/TIG domain
      pfam12796
      Location:717 → 809
      Ank_2; Ankyrin repeats (3 copies)

    3. NM_001190379.1 → NP_001177308.1  calmodulin-binding transcription activator 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK169118, AL596117, BB856280
      Consensus CDS
      CCDS56786.1
      UniProtKB/Swiss-Prot
      Q80Y50
      Related
      ENSMUSP00000104185.3, ENSMUST00000108545.9
      Conserved Domains (4) summary
      sd00045
      Location:688 → 731
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:513 → 592
      TIG; IPT/TIG domain
      pfam12796
      Location:693 → 785
      Ank_2; Ankyrin repeats (3 copies)
      cl04295
      Location:34 → 126
      CG-1; CG-1 domain

    4. NM_001364103.1 → NP_001351032.1  calmodulin-binding transcription activator 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL596117
      Conserved Domains (4) summary
      cd00204
      Location:753 → 851
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:752 → 795
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:577 → 656
      TIG; IPT/TIG domain
      cl04295
      Location:98 → 190
      CG-1; CG-1 domain

    5. NM_178116.4 → NP_835217.1  calmodulin-binding transcription activator 2 isoform 1

      See identical proteins and their annotated locations for NP_835217.1

      Status: VALIDATED

      Source sequence(s)
      AK169118, AL596117, BB856280, BC049133
      Consensus CDS
      CCDS24963.1
      UniProtKB/Swiss-Prot
      B0QZH5, Q3TFK0, Q5SX54, Q5SX68, Q6PHS5, Q80TP1, Q80Y50, Q8R0D9, Q8R2N5
      Related
      ENSMUSP00000043792.8, ENSMUST00000036299.14
      Conserved Domains (5) summary
      smart01076
      Location:34 → 155
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00204
      Location:718 → 816
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01833
      Location:542 → 621
      TIG; IPT/TIG domain
      pfam13637
      Location:718 → 782
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:717 → 760
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70560288..70578966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532919.5 → XP_006532982.1  calmodulin-binding transcription activator 2 isoform X2

      See identical proteins and their annotated locations for XP_006532982.1

      Conserved Domains (4) summary
      smart01076
      Location:98 → 214
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      sd00045
      Location:776 → 819
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:601 → 680
      TIG; IPT/TIG domain
      pfam12796
      Location:781 → 875
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_006532924.4 → XP_006532987.1  calmodulin-binding transcription activator 2 isoform X6

      See identical proteins and their annotated locations for XP_006532987.1

      UniProtKB/TrEMBL
      B0QZH6
      Related
      ENSMUSP00000113667.2, ENSMUST00000120261.8
      Conserved Domains (4) summary
      sd00045
      Location:688 → 731
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:513 → 592
      TIG; IPT/TIG domain
      pfam12796
      Location:693 → 787
      Ank_2; Ankyrin repeats (3 copies)
      cl04295
      Location:34 → 126
      CG-1; CG-1 domain

    3. XM_030245830.2 → XP_030101690.1  calmodulin-binding transcription activator 2 isoform X7

      Conserved Domains (3) summary
      sd00045
      Location:525 → 568
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:350 → 429
      TIG; IPT/TIG domain
      pfam12796
      Location:530 → 624
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_006532918.5 → XP_006532981.1  calmodulin-binding transcription activator 2 isoform X1

      See identical proteins and their annotated locations for XP_006532981.1

      Conserved Domains (4) summary
      smart01076
      Location:98 → 219
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      sd00045
      Location:781 → 824
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:606 → 685
      TIG; IPT/TIG domain
      pfam12796
      Location:786 → 880
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_030245829.2 → XP_030101689.1  calmodulin-binding transcription activator 2 isoform X4

      Conserved Domains (4) summary
      smart01076
      Location:98 → 214
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      sd00045
      Location:776 → 819
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:601 → 680
      TIG; IPT/TIG domain
      pfam12796
      Location:781 → 875
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_030245831.2 → XP_030101691.1  calmodulin-binding transcription activator 2 isoform X8

      Related
      ENSMUST00000125687.2
      Conserved Domains (3) summary
      sd00045
      Location:525 → 568
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:350 → 429
      TIG; IPT/TIG domain
      pfam12796
      Location:530 → 624
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_006532920.5 → XP_006532983.1  calmodulin-binding transcription activator 2 isoform X3

      See identical proteins and their annotated locations for XP_006532983.1

      Conserved Domains (4) summary
      smart01076
      Location:98 → 219
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      sd00045
      Location:781 → 824
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:606 → 685
      TIG; IPT/TIG domain
      pfam12796
      Location:786 → 880
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_006532923.5 → XP_006532986.1  calmodulin-binding transcription activator 2 isoform X5

      See identical proteins and their annotated locations for XP_006532986.1

      Conserved Domains (4) summary
      sd00045
      Location:752 → 795
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:577 → 656
      TIG; IPT/TIG domain
      pfam12796
      Location:757 → 851
      Ank_2; Ankyrin repeats (3 copies)
      cl04295
      Location:98 → 190
      CG-1; CG-1 domain

    RNA

    1. XR_001779953.3 RNA Sequence

      Related
      ENSMUST00000145823.8

    2. XR_879581.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80Y50.1 GenPept UniProtKB/Swiss-Prot:Q80Y50

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