Vpreb3 V-set pre-B cell surrogate light chain 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vpreb3provided by MGI
Official Full Name: V-set pre-B cell surrogate light chain 3provided by MGI
Primary source: MGI:MGI:98938
See related: Ensembl:ENSMUSG00000000903 AllianceGenome:MGI:98938
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 8HS-20; Vpreb-3
Summary: Predicted to be involved in immune response. Predicted to act upstream of or within negative regulation of immunoglobulin production. Predicted to be located in endoplasmic reticulum. Predicted to be part of immunoglobulin complex. Orthologous to human VPREB3 (V-set pre-B cell surrogate light chain 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in spleen adult (RPKM 93.8), ovary adult (RPKM 27.8) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 38.63 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (75778859..75785491)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (75943024..75949657)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pre-B cell receptor (BCR) signals establish the molecular network for BCR signaling even before the production of an IgL Chain and induce the expression of KLF2, a candidate for controlling clonal expansion and migration of functional pre-B cells.
Title: Transcriptome analysis in primary B lymphoid precursors following induction of the pre-B cell receptor.
Detection of functional V(H)81X heavy chains in adult mice with an assessment of complementarity-determining region 3 diversity and capacity to form pre-B cell receptor.
Title: Detection of functional V(H)81X heavy chains in adult mice with an assessment of complementarity-determining region 3 diversity and capacity to form pre-B cell receptor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

D13208 (e-PCR)
- UniSTS:163477

AI528709 (e-PCR)
- UniSTS:185840

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
part_of immunoglobulin complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: pre-B lymphocyte protein 3

Names: pre-B lymphocyte gene 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358532.2 → NP_001345461.1 pre-B lymphocyte protein 3 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC134382

Conserved Domains (1) summary

cl11960
Location:16 → 108

Ig; Immunoglobulin domain
NM_001428879.1 → NP_001415808.1 pre-B lymphocyte protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

AC134382

UniProtKB/TrEMBL

D3Z6J4
NM_009514.6 → NP_033540.1 pre-B lymphocyte protein 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_033540.1

Status: VALIDATED

Source sequence(s)

AC134382

Consensus CDS

CCDS23940.1

UniProtKB/TrEMBL

Q61243

Related

ENSMUSP00000000926.3, ENSMUST00000000926.3

Conserved Domains (2) summary

smart00410
Location:30 → 115

IG_like; Immunoglobulin like

cl11960
Location:30 → 121

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

75778859..75785491

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245072.2 → XP_030100932.1 pre-B lymphocyte protein 3 isoform X1

Related

ENSMUSP00000113205.2, ENSMUST00000121151.2

Conserved Domains (1) summary

cl11960
Location:37 → 128

Ig; Immunoglobulin domain
XM_030245073.2 → XP_030100933.1 pre-B lymphocyte protein 3 isoform X2

Conserved Domains (1) summary

cl11960
Location:27 → 115

Ig; Immunoglobulin domain