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    Rmnd5a required for meiotic nuclear division 5 homolog A [ Mus musculus (house mouse) ]

    Gene ID: 68477, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rmnd5aprovided by MGI
    Official Full Name
    required for meiotic nuclear division 5 homolog Aprovided by MGI
    Primary source
    MGI:MGI:1915727
    See related
    Ensembl:ENSMUSG00000002222 AllianceGenome:MGI:1915727
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gid2; MTA.D02.090; 1110007A06Rik
    Summary
    Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of GID complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human RMND5A (required for meiotic nuclear division 5 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 62.2), cerebellum adult (RPKM 22.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rmnd5a in Genome Data Viewer
    Location:
    6 C1; 6 32.14 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71365623..71417491, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71388634..71440637, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CD8 subunit beta 1 Neighboring gene Cd8 alpha DNase I hypersensitive cluster CIV Neighboring gene Cd8 alpha DNase I hypersensitive cluster CIII Neighboring gene Cd8 alpha DNase I hypersensitive cluster CII Neighboring gene CD8 subunit alpha Neighboring gene STARR-seq mESC enhancer starr_16262 Neighboring gene STARR-positive B cell enhancer ABC_E343 Neighboring gene predicted gene, 30582 Neighboring gene STARR-positive B cell enhancer ABC_E10384 Neighboring gene ring finger protein 103

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential gene expression in CD3epsilon- and RAG1-deficient thymuses: definition of a set of genes potentially involved in thymocyte maturation. Carrier A, et al. Immunogenetics, 1999 Dec. PMID 10630289
    2. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC59617

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of GID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RMND5A
    Names
    protein RMD5 homolog A
    NP_001342674.1
    NP_077250.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355745.2 → NP_001342674.1  E3 ubiquitin-protein ligase RMND5A

      Status: VALIDATED

      Source sequence(s)
      AC154001, AC160090
      Consensus CDS
      CCDS20231.1
      UniProtKB/Swiss-Prot
      E9QNK7, Q3TPH1, Q3UFE2, Q80YQ8
      Conserved Domains (2) summary
      COG5109
      Location:17 → 391
      COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      pfam10607
      Location:153 → 297
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    2. NM_024288.3 → NP_077250.2  E3 ubiquitin-protein ligase RMND5A

      See identical proteins and their annotated locations for NP_077250.2

      Status: VALIDATED

      Source sequence(s)
      AC154001, AC160090
      Consensus CDS
      CCDS20231.1
      UniProtKB/Swiss-Prot
      E9QNK7, Q3TPH1, Q3UFE2, Q80YQ8
      Related
      ENSMUSP00000002292.9, ENSMUST00000002292.15
      Conserved Domains (2) summary
      COG5109
      Location:17 → 391
      COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      pfam10607
      Location:153 → 297
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      71365623..71417491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YQ8.2 GenPept UniProtKB/Swiss-Prot:Q80YQ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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