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    Kcnj12 potassium inwardly-rectifying channel, subfamily J, member 12 [ Mus musculus (house mouse) ]

    Gene ID: 16515, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcnj12provided by MGI
    Official Full Name
    potassium inwardly-rectifying channel, subfamily J, member 12provided by MGI
    Primary source
    MGI:MGI:108495
    See related
    Ensembl:ENSMUSG00000042529 AllianceGenome:MGI:108495
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IRK2; IRK-2; Kir2.2; MB-IRK2
    Summary
    Predicted to enable PDZ domain binding activity and inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane; protein homotetramerization; and regulation of monoatomic ion transmembrane transport. Predicted to be located in T-tubule; dendrite; and neuronal cell body. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and integumental system. Orthologous to several human genes including KCNJ12 (potassium inwardly rectifying channel subfamily J member 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 14.1), heart adult (RPKM 8.7) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcnj12 in Genome Data Viewer
    Location:
    11 B2; 11 37.96 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (60912970..60964095)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61022564..61073269)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2993 Neighboring gene mitogen-activated protein kinase kinase 3 Neighboring gene predicted gene, 35681 Neighboring gene STARR-positive B cell enhancer ABC_E8878 Neighboring gene STARR-positive B cell enhancer ABC_E5234 Neighboring gene STARR-positive B cell enhancer ABC_E8412 Neighboring gene tumor necrosis factor receptor superfamily, member 13b Neighboring gene STARR-positive B cell enhancer ABC_E3956 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:60973670-60973823 Neighboring gene STARR-positive B cell enhancer ABC_E374 Neighboring gene ubiquitin specific peptidase 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse. Oyamada Y, et al. Respir Physiol Neurobiol, 2005 Feb 15. PMID 15705530
    2. Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain. Takahashi N, et al. J Biol Chem, 1994 Sep 16. PMID 8083233
    3. Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation. Zaritsky JJ, et al. Circ Res, 2000 Jul 21. PMID 10904001
    4. The consequences of disrupting cardiac inwardly rectifying K(+) current (I(K1)) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes. Zaritsky JJ, et al. J Physiol, 2001 Jun 15. PMID 11410627, Free PMC Article
    5. Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels. Ishihara K, et al. J Physiol, 2007 Sep 15. PMID 17640933, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction.
      Title: A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction.
    2. Kir2 channels exist in two states having different susceptibilities to internal cationic blockers
      Title: Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels.
    3. Kir2.2 in the brainstem plays a transient role in hypercapnic ventilatory response , possibly through central ventilatory chemosensitivity, during postnatal development.
      Title: Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse.
    4. Computer simulations grounded in biophysical measurements of prelimbic and infralimbic cortex slices suggest a dynamic interaction among Kir2, Kleak, and HCN channel currents in shaping membrane potential and temporal integration of synaptic potentials.
      Title: Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144838, MGC144839

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inward rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in T-tubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-sensitive inward rectifier potassium channel 12
    Names
    inward rectifier K(+) channel Kir2.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267593.1 → NP_001254522.1  ATP-sensitive inward rectifier potassium channel 12 isoform 2

      See identical proteins and their annotated locations for NP_001254522.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK032271, AL646093
      Consensus CDS
      CCDS24805.1
      UniProtKB/Swiss-Prot
      P52187, Q8CCR0, Q9QYF2
      UniProtKB/TrEMBL
      Q9D3L6
      Related
      ENSMUSP00000086588.5, ENSMUST00000089184.11
      Conserved Domains (3) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam08466
      Location:2 → 46
      IRK_N; Inward rectifier potassium channel N-terminal
      pfam17655
      Location:194 → 366
      IRK_C; Inward rectifier potassium channel C-terminal domain

    2. NM_010603.6 → NP_034733.4  ATP-sensitive inward rectifier potassium channel 12 isoform 1

      See identical proteins and their annotated locations for NP_034733.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK017299, AL646093
      Consensus CDS
      CCDS59563.1
      UniProtKB/TrEMBL
      B1ATI1, Q9D3L6
      Related
      ENSMUSP00000041696.3, ENSMUST00000041944.9
      Conserved Domains (4) summary
      PRK07764
      Location:9 → 111
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam01007
      Location:149 → 289
      IRK; Inward rectifier potassium channel
      pfam08466
      Location:104 → 148
      IRK_N; Inward rectifier potassium channel N-terminal
      pfam17655
      Location:296 → 468
      IRK_C; Inward rectifier potassium channel C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      60912970..60964095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156349.1 → XP_036012242.1  ATP-sensitive inward rectifier potassium channel 12 isoform X2

      UniProtKB/Swiss-Prot
      P52187, Q8CCR0, Q9QYF2
      UniProtKB/TrEMBL
      Q9D3L6
      Related
      ENSMUSP00000104357.3, ENSMUST00000108717.3
      Conserved Domains (3) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam08466
      Location:2 → 46
      IRK_N; Inward rectifier potassium channel N-terminal
      pfam17655
      Location:194 → 366
      IRK_C; Inward rectifier potassium channel C-terminal domain

    2. XM_030245606.2 → XP_030101466.1  ATP-sensitive inward rectifier potassium channel 12 isoform X1

      UniProtKB/TrEMBL
      B1ATI1, Q9D3L6
      Conserved Domains (4) summary
      PRK07764
      Location:9 → 111
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam01007
      Location:149 → 289
      IRK; Inward rectifier potassium channel
      pfam08466
      Location:104 → 148
      IRK_N; Inward rectifier potassium channel N-terminal
      pfam17655
      Location:296 → 468
      IRK_C; Inward rectifier potassium channel C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52187.2 GenPept UniProtKB/Swiss-Prot:P52187

    Gene LinkOut

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