Txlng taxilin gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Txlngprovided by MGI
Official Full Name: taxilin gammaprovided by MGI
Primary source: MGI:MGI:3590652
See related: Ensembl:ENSMUSG00000038344 AllianceGenome:MGI:3590652
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lrp; Fiat; 4932441K18Rik
Summary: Predicted to enable DNA-binding transcription factor binding activity. Involved in regulation of bone mineralization and regulation of cell cycle. Located in cytosol and nuclear membrane. Is expressed in femur and tibia. Orthologous to human TXLNG (taxilin gamma). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E18 (RPKM 15.4), liver E14.5 (RPKM 7.3) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F4; X 74.99 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (161561913..161612450, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (162778917..162829454, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our study showed that miR-98 was an important regulator in osteoblast mineralization and miR-98 carried out its function through a novel miR-98-FIAT/Sp7 regulatory loop
Title: miR-98-TXLNG1 (FIAT)/Sp7 function loop mediates osteoblast mineralization.
negative regulator of bone mass acting distinctly on bone formation without alteration in resorption and affecting both the trabecular and the cortical compartments
Title: FIAT Deletion Increases Bone Mass But Does Not Prevent High-Fat-Diet-Induced Metabolic Complications.
We propose that maximal transcriptional repression by FIAT requires its interaction with SUMOylated, HDAC2-interacting aNAC
Title: SUMOylated αNAC potentiates transcriptional repression by FIAT.
The bone phenotype of compound Naca(+/-); Fiat(+/-) heterozygotes confirms that FIAT and alphaNAC are part of a common genetic pathway and support a role for the FIAT/alphaNAC interaction in normal bone physiology.
Title: Altered gene dosage confirms the genetic interaction between FIAT and αNAC.
an interplay between Sp1 and Sp3 as a mechanism involved in the control of Fiat gene expression in osteoblasts.
Title: Control of Fiat (factor inhibiting ATF4-mediated transcription) expression by Sp family transcription factors in osteoblasts.
FIAT can both modulate early osteoblast activity by interacting with ATF4 and regulate later osteoblast function through inhibition of FRA-1.
Title: FIAT, the factor-inhibiting ATF4-mediated transcription, also represses the transcriptional activity of the bZIP factor FRA-1.
Upregulation of MLrgW and MLrgS may be an important component of the LPS inflammatory pathway and of the host response to infection with gram-negative bacteria .
Title: Molecular cloning and functional characterization of a mouse gene upregulated by lipopolysaccharide treatment reveals alternative splicing.
inhibition of FIAT expression increases ATF4 activity and confirm the important role of FIAT in osteoblast function
Title: FIAT inhibition increases osteoblast activity by modulating Atf4-dependent functions.
These results show that FIAT regulates bone mass accrual and establish FIAT as a novel transcriptional regulator of osteoblastic function.(FIAT protein, mouse)
Title: FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1) 1 citation

General gene information

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Markers

RH132537 (e-PCR)
- UniSTS:215820

px-16d5 (e-PCR)
- UniSTS:257325

BB114024 (e-PCR)
- UniSTS:186188

AI173248 (e-PCR)
- UniSTS:181348

RH124898 (e-PCR)
- UniSTS:161720

RH141702 (e-PCR)
- UniSTS:223695

RH136436 (e-PCR)
- UniSTS:210422

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle process	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gamma-taxilin

Names: factor inhibiting activating transcription factor 4 (ATF4)-mediated transcription; lipopolysaccharide-responsive gene protein; lipopolysaccharide-specific response protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290776.1 → NP_001277705.1 gamma-taxilin isoform 2

See identical proteins and their annotated locations for NP_001277705.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AL672123, AV277312, BC117898, BQ128960

Consensus CDS

CCDS72463.1

UniProtKB/Swiss-Prot

Q8BHN1

Related

ENSMUSP00000107935.3, ENSMUST00000112316.9

Conserved Domains (1) summary

pfam09728
Location:89 → 396

Taxilin; Myosin-like coiled-coil protein
NM_001290777.1 → NP_001277706.1 gamma-taxilin isoform 3

See identical proteins and their annotated locations for NP_001277706.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains multiple differences compared to variant 1, including differing in the 3' coding region and 3' UTR. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AK078477, AK162263, AL672123, BY602007

Consensus CDS

CCDS81194.1

UniProtKB/TrEMBL

A2AFJ4, Q3TT61

Related

ENSMUSP00000107934.2, ENSMUST00000112315.2

Conserved Domains (1) summary

pfam09728
Location:89 → 239

Taxilin; Myosin-like coiled-coil protein
NM_001290778.1 → NP_001277707.1 gamma-taxilin isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks multiple 3' coding exons and its terminal exon extends past a splice site used in variant 1, resulting in a different 3' coding region and 3' UTR. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AK162263, AL672123, BY602007

UniProtKB/TrEMBL

Q3TS51

Conserved Domains (1) summary

pfam09728
Location:138 → 288

Taxilin; Myosin-like coiled-coil protein
NM_178935.5 → NP_849266.1 gamma-taxilin isoform 1

See identical proteins and their annotated locations for NP_849266.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK044130, AL672123, AV277312, BC117898, BQ128960

Consensus CDS

CCDS30510.1

UniProtKB/Swiss-Prot

A2AFJ5, Q148Z8, Q2LGB1, Q2PMX1, Q8BHN1, Q8BP11

Related

ENSMUSP00000038615.5, ENSMUST00000041370.11

Conserved Domains (1) summary

pfam09728
Location:138 → 445

Taxilin; Myosin-like coiled-coil protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

161561913..161612450 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006528892.4 → XP_006528955.1 gamma-taxilin isoform X1

Conserved Domains (1) summary

pfam09728
Location:141 → 348

Taxilin; Myosin-like coiled-coil protein