Il10 interleukin 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il10provided by MGI
Official Full Name: interleukin 10provided by MGI
Primary source: MGI:MGI:96537
See related: Ensembl:ENSMUSG00000016529 AllianceGenome:MGI:96537
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CSIF; If2a; Il-10
Summary: This gene encodes an anti-inflammatory cytokine that is a member of the class-2 cytokine family. The encoded protein is secreted by cells of both the innate and adaptive immune systems and is crucial for limiting the immune response to a broad range of pathogens. It also has been shown to suppress autoimmune responses. This protein mediates it's immunosuppressive signal through a specific interleukin 10 receptor complex. Aberrant functioning of this gene is associated with numerous immune disorders including graft-versus-host disease, and increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, Sep 2015]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 56.89 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (130947459..130952707)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (131019845..131024970)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immunomodulatory effects of the induced pluripotent stem cells through expressing IGF-related factors and IL-10 in vitro.
Title: Immunomodulatory effects of the induced pluripotent stem cells through expressing IGF-related factors and IL-10 in vitro.
The role of interleukin-10 in mitigating endoplasmic reticulum stress in aged mice through exercise.
Title: The role of interleukin-10 in mitigating endoplasmic reticulum stress in aged mice through exercise.
Galectin-3-ITGB1 Signaling Mediates Interleukin 10 Production of Hepatic Conventional Natural Killer Cells in Hepatitis B Virus Transgenic Mice and Correlates with Hepatocellular Carcinoma Progression in Patients.
Title: Galectin-3-ITGB1 Signaling Mediates Interleukin 10 Production of Hepatic Conventional Natural Killer Cells in Hepatitis B Virus Transgenic Mice and Correlates with Hepatocellular Carcinoma Progression in Patients.
IL-10 constrains sphingolipid metabolism to limit inflammation.
Title: IL-10 constrains sphingolipid metabolism to limit inflammation.
CPT1A-IL-10-mediated macrophage metabolic and phenotypic alterations ameliorate acute lung injury.
Title: CPT1A-IL-10-mediated macrophage metabolic and phenotypic alterations ameliorate acute lung injury.
The impact of IL-10 and IL-17 on myeloid-derived suppressor cells in vitro and in vivo in a murine model of asthma.
Title: The impact of IL-10 and IL-17 on myeloid-derived suppressor cells in vitro and in vivo in a murine model of asthma.
IL-10 Neutralization Attenuates Mast Cell Responses in a Murine Model of Experimental Food Allergy.
Title: IL-10 Neutralization Attenuates Mast Cell Responses in a Murine Model of Experimental Food Allergy.
Peripheral cytokine interleukin-10 alleviates perihematomal edema after intracerebral hemorrhage via interleukin-10 receptor/JAK1/STAT3 signaling.
Title: Peripheral cytokine interleukin-10 alleviates perihematomal edema after intracerebral hemorrhage via interleukin-10 receptor/JAK1/STAT3 signaling.
Macrophages, IL-10, and nitric oxide increase, induced by hyperglycemic conditions, impact the development of murine melanoma B16F10-Nex2.
Title: Macrophages, IL-10, and nitric oxide increase, induced by hyperglycemic conditions, impact the development of murine melanoma B16F10-Nex2.
Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice.
Title: Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice.

Submit: New GeneRIF Correction See all GeneRIFs (1136)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (11)
Targeted (16) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M37897 (e-PCR)
- UniSTS:178459

Il10 (e-PCR), detects polymorphism
- UniSTS:534563

NoName (e-PCR)
- UniSTS:491333

Il10 (e-PCR), detects polymorphism
- UniSTS:463946

Il10 (e-PCR), detects polymorphism
- UniSTS:143532

PMC96371P1 (e-PCR)
- UniSTS:273626

PMC321611P1 (e-PCR)
- UniSTS:273123

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables interleukin-10 receptor binding	IEA Inferred from Electronic Annotation more info
enables interleukin-10 receptor binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of chronic inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to protozoan	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in interleukin-10-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-10-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of MHC class II biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of MHC class II biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of chronic inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokine activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of heterotypic cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myeloid dendritic cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of B cell apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MHC class II biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of immunoglobulin production	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of plasma cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of plasma cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in response to carbon monoxide	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	ISO Inferred from Sequence Orthology more info
involved_in response to inactivity	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in response to molecule of bacterial origin	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-10

Names: cytokine synthesis inhibitory factor; interferon 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010548.2 → NP_034678.1 interleukin-10 precursor

See identical proteins and their annotated locations for NP_034678.1

Status: REVIEWED

Source sequence(s)

AK152344, AL513351

Consensus CDS

CCDS15265.1

UniProtKB/Swiss-Prot

P18893, Q0VBJ1

UniProtKB/TrEMBL

A0A7R8GUQ3, Q3U879

Related

ENSMUSP00000016673.6, ENSMUST00000016673.6

Conserved Domains (1) summary

pfam00726
Location:15 → 174

IL10; Interleukin 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

130947459..130952707

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162094.1 → XP_036017987.1 interleukin-10 isoform X1

UniProtKB/TrEMBL

Q3U879

Conserved Domains (1) summary

cl02501
Location:15 → 153

IL10; Interleukin 10