Nat8 N-acetyltransferase 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nat8provided by RGD
Official Full Name: N-acetyltransferase 8provided by RGD
Primary source: RGD:621609
See related: EnsemblRapid:ENSRNOG00000078949 AllianceGenome:RGD:621609
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cml4; CCNAT
Summary: Predicted to enable cysteine-S-conjugate N-acetyltransferase activity and lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Predicted to be involved in gastrulation with mouth forming second; peptidyl-lysine N6-acetylation; and positive regulation of gene expression. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 875.9) and Liver (RPKM 82.3) See more
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Genomic context

Location:: 4q34

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (119836986..119837764, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (118279521..118284671, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (117525963..117527443, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyltransferase activity	NAS Non-traceable Author Statement more info	PubMed
enables cysteine-S-conjugate N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-S-conjugate N-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISO Inferred from Sequence Orthology more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in gastrulation with mouth forming second	ISO Inferred from Sequence Orthology more info
involved_in gastrulation with mouth forming second	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutathione metabolic process	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine N6-acetylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine N6-acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: N-acetyltransferase 8

Names: ATase2; N-acetyltransferase 8 (camello like); acetyltransferase 2; camello-like 4; camello-like protein 4; cysteinyl-conjugate N-acetyltransferase; probable N-acetyltransferase CML4; putative N-acetyltransferase Camello 4

NP_072157.1

EC 2.3.1.80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022635.1 → NP_072157.1 N-acetyltransferase 8

See identical proteins and their annotated locations for NP_072157.1

Status: PROVISIONAL

Source sequence(s)

AF185570

UniProtKB/Swiss-Prot

Q9QXT3

UniProtKB/TrEMBL

A6IAT5

Related

ENSRNOP00000021243.3, ENSRNOT00000021243.7

Conserved Domains (2) summary

cd04301
Location:109 → 175

NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate

COG0456
Location:101 → 201

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]