Add2 adducin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Add2provided by RGD
Official Full Name: adducin 2provided by RGD
Primary source: RGD:2042
See related: EnsemblRapid:ENSRNOG00000015903 AllianceGenome:RGD:2042
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: beta-ADD
Summary: Predicted to enable cytoskeletal protein binding activity; protein dimerization activity; and protein kinase binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in monoatomic ion transport. Is active in glutamatergic synapse and postsynapse. Used to study hypertension. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and hypertension. Orthologous to human ADD2 (adducin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 191.0), Brain (RPKM 173.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (120001977..120101090)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (118444594..118538505)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (117691294..117887556)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Darpp32 interaction with beta-adducin may be the molecular pathway by which environmental changes may rapidly alter responsiveness of striatal neurons involved in the reward system.
Title: DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons.
Mutations in the beta subunit of the adducin protein result in damage to renal artery myogenic tone and this is associated with renal damage as manifest by proteinuria.
Title: Mutation in the beta adducin subunit causes tissue-specific damage to myogenic tone.
Data show that the pY489-beta-adducin immunoreactivity is located in the hypothalamic tanycytes and is enhanced after fasting for 36-48 h.
Title: Localization of phospho-tyrosine489-beta-adducin immunoreactivity in the hypothalamic tanycytes and its involvement in energy homeostasis.
Expression of the hypertensive rat or human variant of adducin into normal renal epithelial cells recreates the hypertensive phenotype with higher Na+,K+-ATPase activity, mu2-subunit hyperphosphorylation, and impaired Na+,K+-ATPase endocytosis.
Title: Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase trafficking in response to GPCR signals and intracellular sodium.
beta-adducin plays a role in hypertension
Title: Tissue-specific modulation of beta-adducin transcripts in Milan hypertensive rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables spectrin binding	IEA Inferred from Electronic Annotation more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info
enables structural constituent of cytoskeleton	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IEA Inferred from Electronic Annotation more info
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in barbed-end actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in hemopoiesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	IEA Inferred from Electronic Annotation more info
involved_in leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of F-actin capping protein complex	IEA Inferred from Electronic Annotation more info
part_of F-actin capping protein complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane raft	IEA Inferred from Electronic Annotation more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-adducin

Names: adducin 2 (beta); adducin beta; adducin-63; erythrocyte adducin subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109880.1 → NP_001103350.1 beta-adducin isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AF130338, DY315967, M63894

UniProtKB/Swiss-Prot

Q05764

UniProtKB/TrEMBL

F8WFS9

Conserved Domains (2) summary

PHA00666
Location:578 → 645

PHA00666; putative protease

cl00214
Location:130 → 379

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_012491.2 → NP_036623.1 beta-adducin isoform b

See identical proteins and their annotated locations for NP_036623.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains a distinct 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. The resulting isoform (b) has a shorter, unique C-terminus when compared to isoform a.

Source sequence(s)

BE121149, EV762188, M63894

UniProtKB/TrEMBL

A6IAV0, A6IAV2

Related

ENSRNOP00000073973.1, ENSRNOT00000081173.3

Conserved Domains (1) summary

cl00214
Location:130 → 379

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...