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    Pira2 paired-Ig-like receptor A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361493, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pira2provided by RGD
    Official Full Name
    paired-Ig-like receptor A2provided by RGD
    Primary source
    RGD:1307219
    See related
    AllianceGenome:RGD:1307219
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pirb; Lilrb3; Pir-A1; Pir-A2; Lilrb3l
    Summary
    Predicted to enable inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immune response-regulating signaling pathway. Predicted to be active in plasma membrane. Orthologous to several human genes including LILRB1 (leukocyte immunoglobulin like receptor B1); LILRB2 (leukocyte immunoglobulin like receptor B2); and LILRB3 (leukocyte immunoglobulin like receptor B3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 74.0), Lung (RPKM 51.4) and 9 other tissues See more
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    Genomic context

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    See Pira2 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (74283713..74338208)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (65352125..65422842)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (63759638..63849278)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B2 Neighboring gene uncharacterized LOC120099266 Neighboring gene leukocyte immunoglobulin-like receptor subfamily B member 3-like Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 4 Neighboring gene constitutive coactivator of PPAR-gamma-like protein 1 Neighboring gene leukocyte immunoglobulin like receptor B1 Neighboring gene paired Ig-like receptor B Neighboring gene ribosomal protein S9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lipopolysaccharide induces paired immunoglobulin-like receptor B (PirB) expression, synaptic alteration, and learning-memory deficit in rats. Deng XH, et al. Neuroscience, 2012 May 3. PMID 22395112
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results suggest that PirB modulation may be involved in the pathological process under neurodegenerative conditions
      Title: Lipopolysaccharide induces paired immunoglobulin-like receptor B (PirB) expression, synaptic alteration, and learning-memory deficit in rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables inhibitory MHC class I receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    paired-Ig-like receptor A2
    Names
    Ig-superfamily activating receptor
    leukocyte immunoglobulin like receptor B3 like
    leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
    leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like
    paired Ig-like receptor-A1
    paired Ig-like receptor-B
    six Ig-like domains/type I transmembrane

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419491.1 → NP_001406420.1  paired-Ig-like receptor A2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2KAU3, A6KS11, D3ZVK8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      74283713..74338208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266258.1 → XP_063122328.1  paired-Ig-like receptor A2 isoform X3

    2. XM_063266256.1 → XP_063122326.1  paired-Ig-like receptor A2 isoform X1

    3. XM_063266257.1 → XP_063122327.1  paired-Ig-like receptor A2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2KAU3

    4. XM_006228032.4 → XP_006228094.1  paired-Ig-like receptor A2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2KAU3, A0A8I5ZPR5
      Conserved Domains (2) summary
      smart00410
      Location:529 → 616
      IG_like; Immunoglobulin like
      cl11960
      Location:324 → 416
      Ig; Immunoglobulin domain

    5. XM_006228034.4 → XP_006228096.1  paired-Ig-like receptor A2 isoform X5

      Conserved Domains (2) summary
      smart00410
      Location:434 → 521
      IG_like; Immunoglobulin like
      cl11960
      Location:229 → 321
      Ig; Immunoglobulin domain

    6. XM_063266260.1 → XP_063122330.1  paired-Ig-like receptor A2 isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037357.2: Suppressed sequence

      Description
      NM_001037357.2: This RefSeq was removed because currently there is insufficient support for the transcript
    Nucleotide Protein Strain
    Heading Accession and Version

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