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    MEI1 transcription coactivator [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844068, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MEI1
    Official Full Name
    transcription coactivator
    Primary source
    TAIR:AT1G77320
    Locus tag
    AT1G77320
    See related
    Araport:AT1G77320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2P24.3; F2P24_3; meiosis defective 1
    Summary
    Mutant is defective in meiosis and produces abnormal microspores. Encodes a BRCT-domain-containing protein that could be specific to the meiotic cell cycle and that plays a crucial role in some DNA repair events independent of SPO11 DSB recombination repair.
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    Genomic context

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    See MEI1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    17
    Sequence:
    Chromosome: 1; NC_003070.9 (29056427..29062978)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene kinase with adenine nucleotide alpha hydrolases-like domain-containing protein Neighboring gene Glutathione S-transferase family protein Neighboring gene histone-lysine N-methyltransferase Neighboring gene wound-responsive family protein Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene keratinocyte-associated-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis MEI1 gene encodes a protein with five BRCT domains that is involved in meiosis-specific DNA repair events independent of SPO11-induced DSBs. Grelon M, et al. Plant J, 2003 Aug. PMID 12904209
    2. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001198489.1
    NM_001334776.1
    NM_106381.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within reciprocal meiotic recombination TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    transcription coactivator
    NP_001185418.1
    • meiosis defective 1 (MEI1); FUNCTIONS IN: transcription coactivator activity; INVOLVED IN: female meiosis, reciprocal meiotic recombination, response to DNA damage stimulus, male meiosis; LOCATED IN: intracellular; CONTAINS InterPro DOMAIN/s: BRCT (InterPro:IPR001357).
    NP_177856.2
    • meiosis defective 1 (MEI1); FUNCTIONS IN: transcription coactivator activity; INVOLVED IN: female meiosis, reciprocal meiotic recombination, response to DNA damage stimulus, male meiosis; LOCATED IN: intracellular; CONTAINS InterPro DOMAIN/s: BRCT (InterPro:IPR001357); BEST Arabidopsis thaliana protein match is: BRCT domain-containing DNA repair protein (TAIR:AT3G43930.2); Has 1189 Blast hits to 732 proteins in 163 species: Archae - 0; Bacteria - 0; Metazoa - 465; Fungi - 465; Plants - 183; Viruses - 0; Other Eukaryotes - 76 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29056427..29062978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106381.3 → NP_177856.2  transcription coactivator [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177856.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WAL0, F4I701, Q70X85
      Conserved Domains (3) summary
      smart00292
      Location:366 → 439
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:102 → 169
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam12738
      Location:188 → 251
      PTCB-BRCT; twin BRCT domain

    2. NM_001334776.1 → NP_001323210.1  transcription coactivator [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WAL0, A0A1P8AWF3, Q70X85

    3. NM_001198489.1 → NP_001185418.1  transcription coactivator [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185418.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WV49, F4I702
      Conserved Domains (3) summary
      smart00292
      Location:349 → 422
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:95 → 162
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam12738
      Location:650 → 712
      PTCB-BRCT; twin BRCT domain
    Nucleotide Protein
    Heading Accession and Version

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