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    Orc3 origin recognition complex, subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 50793, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Orc3provided by MGI
    Official Full Name
    origin recognition complex, subunit 3provided by MGI
    Primary source
    MGI:MGI:1354944
    See related
    Ensembl:ENSMUSG00000040044 AllianceGenome:MGI:1354944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Orc3l
    Summary
    Predicted to enable DNA replication origin binding activity. Acts upstream of or within glial cell proliferation and neural precursor cell proliferation. Predicted to be located in chromatin and nuclear body. Predicted to be part of DNA replication preinitiation complex; nuclear origin of replication recognition complex; and nuclear pre-replicative complex. Orthologous to human ORC3 (origin recognition complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 7.3), whole brain E14.5 (RPKM 6.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Orc3 in Genome Data Viewer
    Location:
    4 A5; 4 16.81 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (34566781..34614942, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (34566781..34614963, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33434 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09910 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:34497692-34497879 Neighboring gene akirin 2 Neighboring gene STARR-seq mESC enhancer starr_09912 Neighboring gene arginyl-tRNA synthetase 2, mitochondrial Neighboring gene solute carrier family 35 (CMP-sialic acid transporter), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E6160 Neighboring gene cilia and flagella associated protein 206 Neighboring gene STARR-seq mESC enhancer starr_09914

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A functional requirement for astroglia in promoting blood vessel development in the early postnatal brain. Ma S, et al. PLoS One, 2012. PMID 23110156, Free PMC Article
    2. Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex. Springer J, et al. Cytogenet Cell Genet, 1999. PMID 10702681
    3. Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation. Miyake Y, et al. J Biol Chem, 2005 Apr 1. PMID 15634681
    4. Radial glia regulate Cajal-Retzius cell positioning in the early embryonic cerebral cortex. Kwon HJ, et al. Dev Biol, 2011 Mar 1. PMID 21185282
    5. The dynamic nature of the human origin recognition complex revealed through five cryoEM structures. Jaremko MJ, et al. Elife, 2020 Aug 18. PMID 32808929, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear origin of replication recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear origin of replication recognition complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of nuclear origin of replication recognition complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of nuclear pre-replicative complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of origin recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    origin recognition complex subunit 3
    Names
    origin of replication 3 homolog
    origin recognition complex subunit Latheo

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159563.1 → NP_001153035.1  origin recognition complex subunit 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, that results in a protein (isoform 2) that is one amino acid shorter than isoform 1.
      Source sequence(s)
      AB190257, AK041216, AK045388, AK086579, BB663298
      Consensus CDS
      CCDS51137.1
      UniProtKB/TrEMBL
      Q3ULT0
      Related
      ENSMUSP00000103777.2, ENSMUST00000108142.8
      Conserved Domains (1) summary
      pfam07034
      Location:25 → 350
      ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus

    2. NM_015824.4 → NP_056639.3  origin recognition complex subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_056639.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK041216, AK045388, AK086579, BB663298
      Consensus CDS
      CCDS18028.1
      UniProtKB/Swiss-Prot
      A2AMF4, A2AMF5, Q6P8H2, Q8BR83, Q8C395, Q9JK30
      UniProtKB/TrEMBL
      Q3ULT0
      Related
      ENSMUSP00000048319.4, ENSMUST00000048706.10
      Conserved Domains (1) summary
      pfam07034
      Location:25 → 350
      ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      34566781..34614942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320309.3 → XP_017175798.1  origin recognition complex subunit 3 isoform X2

      Conserved Domains (2) summary
      pfam07034
      Location:3 → 203
      ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
      pfam18137
      Location:456 → 565
      ORC_WH_C; Origin recognition complex winged helix C-terminal

    2. XM_030253654.2 → XP_030109514.1  origin recognition complex subunit 3 isoform X3

      Conserved Domains (2) summary
      pfam07034
      Location:3 → 203
      ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
      pfam18137
      Location:455 → 564
      ORC_WH_C; Origin recognition complex winged helix C-terminal

    3. XM_030253653.2 → XP_030109513.1  origin recognition complex subunit 3 isoform X1

      Conserved Domains (1) summary
      pfam07034
      Location:25 → 350
      ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus

    4. XM_011250066.4 → XP_011248368.1  origin recognition complex subunit 3 isoform X4

      Conserved Domains (1) summary
      pfam07034
      Location:25 → 350
      ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JK30.1 GenPept UniProtKB/Swiss-Prot:Q9JK30

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