Trpc3 transient receptor potential cation channel, subfamily C, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trpc3provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily C, member 3provided by MGI
Primary source: MGI:MGI:109526
See related: Ensembl:ENSMUSG00000027716 AllianceGenome:MGI:109526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mwk; Trp3; Trcp3; Trrp3
Summary: Predicted to enable calcium-activated cation channel activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Predicted to be involved in several processes, including positive regulation of calcium ion transport into cytosol; positive regulation of cardiac muscle hypertrophy in response to stress; and response to ATP. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cochlea; ganglia; skeletal muscle; spinal cord; and trunk somite. Human ortholog(s) of this gene implicated in cerebellar ataxia type 41. Orthologous to human TRPC3 (transient receptor potential cation channel subfamily C member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 16.9), CNS E18 (RPKM 4.1) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 B; 3 17.93 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (36674626..36744276, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (36620482..36690429, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced TRPC3 transcription through AT1R/PKA/CREB signaling contributes to mitochondrial dysfunction in renal tubular epithelial cells in D-galactose-induced accelerated aging mice.
Title: Enhanced TRPC3 transcription through AT1R/PKA/CREB signaling contributes to mitochondrial dysfunction in renal tubular epithelial cells in D-galactose-induced accelerated aging mice.
New insights in the renal distribution profile of TRPC3 - Of mice and men.
Title: New insights in the renal distribution profile of TRPC3 - Of mice and men.
Canonical Transient Receptor Potential Channel 3 Contributes to Cerebral Blood Flow Changes Associated with Cortical Spreading Depression in Mice.
Title: Canonical Transient Receptor Potential Channel 3 Contributes to Cerebral Blood Flow Changes Associated with Cortical Spreading Depression in Mice.
Role of TRPC3 in Right Ventricular Dilatation under Chronic Intermittent Hypoxia in 129/SvEv Mice.
Title: Role of TRPC3 in Right Ventricular Dilatation under Chronic Intermittent Hypoxia in 129/SvEv Mice.
Sensory neuron-expressed TRPC3 mediates acute and chronic itch.
Title: Sensory neuron-expressed TRPC3 mediates acute and chronic itch.
TRPC3 Regulates Islet Beta-Cell Insulin Secretion.
Title: TRPC3 Regulates Islet Beta-Cell Insulin Secretion.
Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells.
Title: Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells.
Increase in membrane surface expression and phosphorylation of TRPC3 related to olfactory dysfunction in alpha-synuclein transgenic mice.
Title: Increase in membrane surface expression and phosphorylation of TRPC3 related to olfactory dysfunction in α-synuclein transgenic mice.
Sodium-Glucose Cotransporter 2 Inhibitor Canagliflozin Antagonizes Salt-Sensitive Hypertension Through Modifying Transient Receptor Potential Channels 3 Mediated Vascular Calcium Handling.
Title: Sodium-Glucose Cotransporter 2 Inhibitor Canagliflozin Antagonizes Salt-Sensitive Hypertension Through Modifying Transient Receptor Potential Channels 3 Mediated Vascular Calcium Handling.
A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.
Title: A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.

Submit: New GeneRIF Correction See all GeneRIFs (91)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trpc3 (e-PCR), detects polymorphism
- UniSTS:546049

Trpc3 (e-PCR), detects polymorphism
- UniSTS:531240

Trrp3 (e-PCR), detects polymorphism
- UniSTS:144684

Trpc3 (e-PCR), detects polymorphism
- UniSTS:516713

Trpc3 (e-PCR), detects polymorphism
- UniSTS:516714

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-activated cation channel activity	IEA Inferred from Electronic Annotation more info
enables calcium-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5 trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables store-operated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport into cytosol	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle hypertrophy in response to stress	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ATP	IEA Inferred from Electronic Annotation more info
involved_in response to ATP	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: short transient receptor potential channel 3

Names: TRP-3; mTrp3; receptor-activated cation channel TRP3; transient receptor protein 3; trp-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403842.1 → NP_001390771.1 short transient receptor potential channel 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC117584
NM_019510.3 → NP_062383.2 short transient receptor potential channel 3 isoform 1

See identical proteins and their annotated locations for NP_062383.2

Status: VALIDATED

Source sequence(s)

AC117584

Consensus CDS

CCDS50893.1

UniProtKB/Swiss-Prot

B1ATV3, Q61058, Q9QZC1

UniProtKB/TrEMBL

Q8CCQ1

Related

ENSMUSP00000029271.5, ENSMUST00000029271.5

Conserved Domains (4) summary

cd00204
Location:108 → 242

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:85 → 879

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:256 → 315

TRP_2; Transient receptor ion channel II

sd00045
Location:135 → 166

ANK; ANK repeat [structural motif]