Dcaf12 DDB1 and CUL4 associated factor 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcaf12provided by MGI
Official Full Name: DDB1 and CUL4 associated factor 12provided by MGI
Primary source: MGI:MGI:1916220
See related: Ensembl:ENSMUSG00000028436 AllianceGenome:MGI:1916220
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wdr40a; 1500001L20Rik; 5830424K06Rik
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in T cell activation and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in centrosome. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytosol. Orthologous to human DCAF12 (DDB1 and CUL4 associated factor 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 28.9), liver E14 (RPKM 16.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 21.32 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (41291300..41316749, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (41291300..41316749, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124273 (e-PCR)
- UniSTS:161095

AI851081 (e-PCR)
- UniSTS:165321

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in T cell activation	IEA Inferred from Electronic Annotation more info
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of regulation of autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DDB1- and CUL4-associated factor 12

Names: WD repeat domain 40A; WD repeat-containing protein 40A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026893.3 → NP_081169.2 DDB1- and CUL4-associated factor 12

See identical proteins and their annotated locations for NP_081169.2

Status: VALIDATED

Source sequence(s)

AA207929, AK031089, AK173289, BY338453

Consensus CDS

CCDS18059.1

UniProtKB/Swiss-Prot

Q69Z77, Q8BGZ3, Q8BN60, Q8C1Y4, Q9DB95

Related

ENSMUSP00000030145.9, ENSMUST00000030145.9

Conserved Domains (3) summary

COG2319
Location:103 → 378

WD40; WD40 repeat [General function prediction only]

sd00039
Location:144 → 180

7WD40; WD40 repeat [structural motif]

cl02567
Location:85 → 279

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

41291300..41316749 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538230.4 → XP_006538293.1 DDB1- and CUL4-associated factor 12 isoform X4

See identical proteins and their annotated locations for XP_006538293.1
XM_006538229.4 → XP_006538292.1 DDB1- and CUL4-associated factor 12 isoform X2

Conserved Domains (2) summary

sd00039
Location:120 → 156

7WD40; WD40 repeat [structural motif]

cl29593
Location:61 → 255

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006538228.4 → XP_006538291.1 DDB1- and CUL4-associated factor 12 isoform X1

Conserved Domains (2) summary

sd00039
Location:138 → 174

7WD40; WD40 repeat [structural motif]

cl29593
Location:79 → 273

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036164402.1 → XP_036020295.1 DDB1- and CUL4-associated factor 12 isoform X4
XM_017320381.3 → XP_017175870.1 DDB1- and CUL4-associated factor 12 isoform X4
XM_036164401.1 → XP_036020294.1 DDB1- and CUL4-associated factor 12 isoform X3

Conserved Domains (2) summary

sd00039
Location:90 → 130

7WD40; WD40 repeat [structural motif]

cl29593
Location:85 → 297

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...