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    MGC16025 uncharacterized LOC85009 [ Homo sapiens (human) ]

    Gene ID: 85009, updated on 10-Dec-2024

    Summary

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    Gene symbol
    MGC16025
    Gene description
    uncharacterized LOC85009
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
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    Genomic context

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    See MGC16025 in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (239193331..239195457, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (239684488..239686614, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (240115027..240117153, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene histone deacetylase 4 Neighboring gene microRNA 4441 Neighboring gene uncharacterized LOC124908009 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240111156-240111673 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240111674-240112190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240112520-240113118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240117946-240118446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240123022-240123588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240134871-240135376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240136104-240136802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240136803-240137501 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240146814-240147708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240152211-240152711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240153455-240153994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240165567-240166264 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:240168807-240170006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240174119-240174620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240183749-240184248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240185799-240186466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17385 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240194739-240195516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17386 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:240197413-240197621 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240213415-240213946 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:240212885-240213414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12499 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:240217222-240217838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240217839-240218454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17387 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240229260-240229906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:240232601-240233101 Neighboring gene microRNA 4269 Neighboring gene microRNA 2467

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. IRES-dependent translation of the long non coding RNA meloe in melanoma cells produces the most immunogenic MELOE antigens. Charpentier M, et al. Oncotarget, 2016 Sep 13. PMID 27486971, Free PMC Article
    2. Overexpression of meloe gene in melanomas is controlled both by specific transcription factors and hypomethylation. Bobinet M, et al. PLoS One, 2013. PMID 24086527, Free PMC Article
    3. The melanoma antigens MELOE-1 and MELOE-2 are translated from a bona fide polycistronic mRNA containing functional IRES sequences. Carbonnelle D, et al. PLoS One, 2013. PMID 24086473, Free PMC Article
    4. Frequent occurrence of high affinity T cells against MELOE-1 makes this antigen an attractive target for melanoma immunotherapy. Godet Y, et al. Eur J Immunol, 2010 Jun. PMID 20217862
    5. MELOE-1 is a new antigen overexpressed in melanomas and involved in adoptive T cell transfer efficiency. Godet Y, et al. J Exp Med, 2008 Oct 27. PMID 18936238, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate the expression of an additional ORF, MELOE-3, located in the 5' region of meloe.
      Title: IRES-dependent translation of the long non coding RNA meloe in melanoma cells produces the most immunogenic MELOE antigens.
    2. Overexpression of meloe gene in melanomas is controlled both by specific transcription factors and hypomethylation.
      Title: Overexpression of meloe gene in melanomas is controlled both by specific transcription factors and hypomethylation.
    3. meloe is a polycistronic mRNA that generates both MELOE-1 and MELOE-2 antigens through IRES-dependent translation in melanoma cells and that may explain their tumor specificity.
      Title: The melanoma antigens MELOE-1 and MELOE-2 are translated from a bona fide polycistronic mRNA containing functional IRES sequences.
    4. study documents the existence of a large TCR repertoire specific for the MELOE-1/A2 epitope
      Title: Frequent occurrence of high affinity T cells against MELOE-1 makes this antigen an attractive target for melanoma immunotherapy.
    5. MELOE-1 is a new antigen overexpressed in melanomas and involved in adoptive T cell transfer efficiency.
      Title: MELOE-1 is a new antigen overexpressed in melanomas and involved in adoptive T cell transfer efficiency.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026664.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC017028

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      239193331..239195457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      239684488..239686614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032923.1: Suppressed sequence

      Description
      NM_032923.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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