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    RNF157 ring finger protein 157 [ Homo sapiens (human) ]

    Gene ID: 114804, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RNF157provided by HGNC
    Official Full Name
    ring finger protein 157provided by HGNC
    Primary source
    HGNC:HGNC:29402
    See related
    Ensembl:ENSG00000141576 AllianceGenome:HGNC:29402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of apoptotic process; positive regulation of dendrite extension; and protein ubiquitination. Predicted to be located in cell body. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 16.0), testis (RPKM 13.4) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RNF157 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (76142474..76240493, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (77039017..77137048, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74138555..74236574, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74127821-74128482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74128483-74129142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74133109-74133770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74133771-74134430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74135093-74135752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9003 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9005 Neighboring gene RNF157 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74140914-74141462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74141463-74142010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74143158-74143658 Neighboring gene forkhead box J1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:74162894-74164093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74186853-74187352 Neighboring gene ATP synthase membrane subunit g pseudogene 6 Neighboring gene activating transcription factor 4 pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74235542-74236214 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9007 Neighboring gene uncharacterized LOC105371896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12794 Neighboring gene Sharpr-MPRA regulatory region 14042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12800 Neighboring gene UBA like domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The E3 Ligase RNF157 Inhibits Lens Epithelial Cell Apoptosis by Negatively Regulating p53 in Age-Related Cataracts. Qi T, et al. Invest Ophthalmol Vis Sci, 2022 Apr 1. PMID 35435923, Free PMC Article
    2. Exosomal RNF157 mRNA from prostate cancer cells contributes to M2 macrophage polarization through destabilizing HDAC1. Guan H, et al. Front Oncol, 2022. PMID 36263220, Free PMC Article
    3. Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle. Dogan T, et al. J Biol Chem, 2017 Sep 1. PMID 28655764, Free PMC Article
    4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. Nagase T, et al. DNA Res, 2001 Aug 31. PMID 11572484
    5. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. van Wijk SJ, et al. Mol Syst Biol, 2009. PMID 19690564, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that RNF157 plays role as downstream effector of both PI3K signaling and MAPK signaling in melanoma cell line; regulation of RNF157 expression is cell-cycle-dependent in melanoma cell line; both CDH1 and CDK2 are involved in modulation of RNF157 stability during melanoma cell proliferation. (PI3K = phosphatidylinositol 3-kinase; CDH1 = E-cadherin; CDK2 = cyclin-dependent kinase 2)
      Title: Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.
    2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of dendrite extension ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin ligase RNF157
    Names
    RING-type E3 ubiquitin transferase RNF157
    NP_001317430.1
    NP_443148.1
    XP_011522575.1
    XP_016879609.2
    XP_047291242.1
    XP_047291243.1
    XP_047291244.1
    XP_047291245.1
    XP_054170911.1
    XP_054170912.1
    XP_054170913.1
    XP_054170914.1
    XP_054170915.1
    XP_054170916.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330501.2 → NP_001317430.1  E3 ubiquitin ligase RNF157 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA609513, AB067504, AC015801, AK091467, BM310065, BM722923, BQ434552, CX872674
      Consensus CDS
      CCDS82208.1
      UniProtKB/Swiss-Prot
      Q96PX1
      Related
      ENSP00000321837.4, ENST00000319945.10

    2. NM_052916.3 → NP_443148.1  E3 ubiquitin ligase RNF157 isoform 1

      See identical proteins and their annotated locations for NP_443148.1

      Status: VALIDATED

      Source sequence(s)
      AA932192, AB067504, AC015801, AK055949, AK091467, BI857136, BM474134, CX872674
      Consensus CDS
      CCDS32740.1
      UniProtKB/Swiss-Prot
      Q8NB72, Q96N56, Q96PX1
      Related
      ENSP00000269391.4, ENST00000269391.11
      Conserved Domains (1) summary
      pfam13920
      Location:276 → 318
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      76142474..76240493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435287.1 → XP_047291243.1  E3 ubiquitin ligase RNF157 isoform X2

    2. XM_047435286.1 → XP_047291242.1  E3 ubiquitin ligase RNF157 isoform X1

      UniProtKB/TrEMBL
      A0A3B3ISM3
      Related
      ENSP00000497353.1, ENST00000647930.1

    3. XM_047435288.1 → XP_047291244.1  E3 ubiquitin ligase RNF157 isoform X3

    4. XM_017024120.3 → XP_016879609.2  E3 ubiquitin ligase RNF157 isoform X4

    5. XM_011524273.4 → XP_011522575.1  E3 ubiquitin ligase RNF157 isoform X6

      Conserved Domains (1) summary
      pfam13920
      Location:276 → 318
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    6. XM_047435289.1 → XP_047291245.1  E3 ubiquitin ligase RNF157 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      77039017..77137048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314937.1 → XP_054170912.1  E3 ubiquitin ligase RNF157 isoform X2

    2. XM_054314936.1 → XP_054170911.1  E3 ubiquitin ligase RNF157 isoform X1

    3. XM_054314938.1 → XP_054170913.1  E3 ubiquitin ligase RNF157 isoform X3

    4. XM_054314939.1 → XP_054170914.1  E3 ubiquitin ligase RNF157 isoform X4

    5. XM_054314941.1 → XP_054170916.1  E3 ubiquitin ligase RNF157 isoform X6

    6. XM_054314940.1 → XP_054170915.1  E3 ubiquitin ligase RNF157 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96PX1.3 GenPept UniProtKB/Swiss-Prot:Q96PX1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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