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    IFI44L interferon induced protein 44 like [ Homo sapiens (human) ]

    Gene ID: 10964, updated on 10-Dec-2024

    Summary

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    Official Symbol
    IFI44Lprovided by HGNC
    Official Full Name
    interferon induced protein 44 likeprovided by HGNC
    Primary source
    HGNC:HGNC:17817
    See related
    Ensembl:ENSG00000137959 MIM:613975; AllianceGenome:HGNC:17817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GS3686; TLDC5B; C1orf29
    Summary
    Predicted to be involved in immune response. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen (RPKM 16.8), bone marrow (RPKM 13.1) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IFI44L in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (78620448..78646145)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (78459314..78485000)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (79086133..79111830)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 23 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:78957125-78957657 Neighboring gene prostaglandin F receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1237 Neighboring gene interferon induced protein 44 Neighboring gene ribosomal protein L23 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Novel polymorphism of IFI44L associated with the susceptibility and clinical characteristics of systemic lupus erythematosus in a Chinese population. Zhang Q, et al. Int Immunopharmacol, 2023 Apr. PMID 36893516
    2. IFI44L is a novel tumor suppressor in human hepatocellular carcinoma affecting cancer stemness, metastasis, and drug resistance via regulating met/Src signaling pathway. Huang WC, et al. BMC Cancer, 2018 May 30. PMID 29848298, Free PMC Article
    3. Associations Between IFI44L Gene Variants and Rates of Respiratory Tract Infections During Early Childhood. Lempainen J, et al. J Infect Dis, 2021 Jan 4. PMID 32561935
    4. IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses. Jiang H, et al. J Immunol Res, 2021. PMID 34722780, Free PMC Article
    5. The prognostic and clinical significance of IFI44L aberrant downregulation in patients with oral squamous cell carcinoma. Ou D, et al. BMC Cancer, 2021 Dec 13. PMID 34903206, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ACSL4 upregulates IFI44 and IFI44L expression and promotes the proliferation and invasiveness of head and neck squamous cell carcinoma cells.
      Title: ACSL4 upregulates IFI44 and IFI44L expression and promotes the proliferation and invasiveness of head and neck squamous cell carcinoma cells.
    2. Novel polymorphism of IFI44L associated with the susceptibility and clinical characteristics of systemic lupus erythematosus in a Chinese population.
      Title: Novel polymorphism of IFI44L associated with the susceptibility and clinical characteristics of systemic lupus erythematosus in a Chinese population.
    3. Reciprocal expression of the immune response genes CXCR3 and IFI44L as module hubs are associated with patient survivals in primary central nervous system lymphoma.
      Title: Reciprocal expression of the immune response genes CXCR3 and IFI44L as module hubs are associated with patient survivals in primary central nervous system lymphoma.
    4. IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis.
      Title: IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis.
    5. Identification of IFI44L as a new candidate molecular marker for systemic lupus erythematosus.
      Title: Identification of IFI44L as a new candidate molecular marker for systemic lupus erythematosus.
    6. Epigenetic Regulation of IFI44L Expression in Monocytes Affects the Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus Erythematosus.
      Title: Epigenetic Regulation of IFI44L Expression in Monocytes Affects the Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus Erythematosus.
    7. Differentially methylation of IFI44L gene promoter in Iranian patients with systemic lupus erythematosus and rheumatoid arthritis.
      Title: Differentially methylation of IFI44L gene promoter in Iranian patients with systemic lupus erythematosus and rheumatoid arthritis.
    8. The prognostic and clinical significance of IFI44L aberrant downregulation in patients with oral squamous cell carcinoma.
      Title: The prognostic and clinical significance of IFI44L aberrant downregulation in patients with oral squamous cell carcinoma.
    9. IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses.
      Title: IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses.
    10. Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy.
      Title: Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common variants associated with general and MMR vaccine-related febrile seizures.
    EBI GWAS Catalog
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    EBI GWAS Catalog
    Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of interferon-induced protein 44-like (IFI44L) in human B cells PubMed
    env HIV-1 gp120-treated vaginal epithelial cells show upregulation of interferon-induced protein 44-like (IFI44L) expression as compared to untreated control PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of IFI44L in human monocyte-derived dendritic cells PubMed
    vpr HIV-1 Vpr upregulates the gene expression of IFI44L in human monocyte-derived macrophages PubMed
    Vpu vpu The expression of IFI44L mRNA increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates IFI44L protein expression PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interferon-induced protein 44-like

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001375646.1 → NP_001362575.1  interferon-induced protein 44-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC104837
      Consensus CDS
      CCDS687.2
      UniProtKB/Swiss-Prot
      Q53G44, Q86TE1, Q96B64, Q99984
      UniProtKB/TrEMBL
      B2R5Q5
      Conserved Domains (1) summary
      cd00882
      Location:201 → 286
      Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)

    2. NM_001375647.1 → NP_001362576.1  interferon-induced protein 44-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104837
      Consensus CDS
      CCDS90985.1
      UniProtKB/TrEMBL
      B4E019
      Related
      ENSP00000504938.1, ENST00000679998.1

    3. NM_001375648.1 → NP_001362577.1  interferon-induced protein 44-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104837, AK223087, AK303187
      Consensus CDS
      CCDS90985.1
      UniProtKB/TrEMBL
      B4E019
      Related
      ENSP00000506722.1, ENST00000680295.1

    4. NM_001375649.1 → NP_001362578.1  interferon-induced protein 44-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104837
      Consensus CDS
      CCDS90985.1
      UniProtKB/TrEMBL
      B4E019
      Related
      ENSP00000506384.1, ENST00000681613.1

    5. NM_001375650.1 → NP_001362579.1  interferon-induced protein 44-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104837
      Consensus CDS
      CCDS90985.1
      UniProtKB/TrEMBL
      B4E019
      Related
      ENSP00000506096.1, ENST00000459784.6

    6. NM_006820.4 → NP_006811.2  interferon-induced protein 44-like isoform 1

      See identical proteins and their annotated locations for NP_006811.2

      Status: VALIDATED

      Source sequence(s)
      AC104837, AK225442, AW015958, DC390321
      Consensus CDS
      CCDS687.2
      UniProtKB/Swiss-Prot
      Q53G44, Q86TE1, Q96B64, Q99984
      UniProtKB/TrEMBL
      B2R5Q5
      Related
      ENSP00000359787.4, ENST00000370751.10
      Conserved Domains (1) summary
      cd00882
      Location:201 → 286
      Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      78620448..78646145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006710304.5 → XP_006710367.1  interferon-induced protein 44-like isoform X1

      See identical proteins and their annotated locations for XP_006710367.1

      UniProtKB/TrEMBL
      B4E019

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      78459314..78485000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333956.1 → XP_054189931.1  interferon-induced protein 44-like isoform X1

      UniProtKB/TrEMBL
      B4E019
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53G44.3 GenPept UniProtKB/Swiss-Prot:Q53G44

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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