ZFPL1 zinc finger protein like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZFPL1provided by HGNC
Official Full Name: zinc finger protein like 1provided by HGNC
Primary source: HGNC:HGNC:12868
See related: Ensembl:ENSG00000162300 MIM:619397; AllianceGenome:HGNC:12868
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MCG4; D11S750
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in vesicle-mediated transport. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis (RPKM 12.5), ovary (RPKM 11.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (65084222..65088398)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (65077500..65081676)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (64851694..64855870)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zinc finger proteinlike 1 is a novel neuroendocrine biomarker for prostate cancer.
Title: Zinc finger protein‑like 1 is a novel neuroendocrine biomarker for prostate cancer.
The RING domain was essential for the function of ZFPL1.
Title: RING domain of zinc finger protein like 1 is essential for cell proliferation in endometrial cancer cell line RL95-2.
These results suggest that ZFPL1 may serve an important role in regulating autophagy in NCIN87 and BGC823 cells.
Title: Knockdown of ZFPL1 results in increased autophagy and autophagy‑related cell death in NCI‑N87 and BGC‑823 human gastric carcinoma cell lines.
These data suggest that ZFPL1 has an important function in maintaining the integrity of the cis-Golgi and that it does so through interactions with GM130.
Title: ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH92166 (e-PCR)
- UniSTS:92220

SGC33858 (e-PCR)
- UniSTS:75943

REN72948 (e-PCR)
- UniSTS:397748

RH11465 (e-PCR)
- UniSTS:50642

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: zinc finger protein-like 1

Names: zinc finger protein MCG4; zinc-finger protein in MEN1 region

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006782.4 → NP_006773.2 zinc finger protein-like 1

See identical proteins and their annotated locations for NP_006773.2

Status: VALIDATED

Source sequence(s)

AF030291, AI207587, AU279924

Consensus CDS

CCDS8092.1

UniProtKB/Swiss-Prot

A8K7E9, O14616, O95159, Q9UID0

Related

ENSP00000294258.3, ENST00000294258.8

Conserved Domains (1) summary

cd16487
Location:50 → 104

mRING-H2-C3DHC3_ZFPL1; Modified RING finger, H2 subclass (C3DHC3-type), found in zinc finger protein-like 1 (ZFPL1) and similar proteins