RAE1 ribonucleic acid export 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAE1provided by HGNC
Official Full Name: ribonucleic acid export 1provided by HGNC
Primary source: HGNC:HGNC:9828
See related: Ensembl:ENSG00000101146 MIM:603343; AllianceGenome:HGNC:9828
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Gle2; MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1
Summary: Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 35.7), bone marrow (RPKM 13.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.31

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (57351255..57379202)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (59128709..59156957)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (55926311..55954258)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SARS-CoV-2 Orf6 is positioned in the nuclear pore complex by Rae1 to inhibit nucleocytoplasmic transport.
Title: SARS-CoV-2 Orf6 is positioned in the nuclear pore complex by Rae1 to inhibit nucleocytoplasmic transport.
Insights into the SARS-CoV-2 ORF6 Mechanism of Action.
Title: Insights into the SARS-CoV-2 ORF6 Mechanism of Action.
Super-Enhancer-Driven RAE1 Shows Higher Protein Levels in Tumor Compared to Adjacent Nonmalignant Stroma in High-Grade Serous Ovarian Cancer Patients.
Title: Super-Enhancer-Driven RAE1 Shows Higher Protein Levels in Tumor Compared to Adjacent Nonmalignant Stroma in High-Grade Serous Ovarian Cancer Patients.
Mitotic checkpoint regulator RAE1 promotes tumor growth in colorectal cancer.
Title: Mitotic checkpoint regulator RAE1 promotes tumor growth in colorectal cancer.
Lysine acetylation of NKG2D ligand Rae-1 stabilizes the protein and sensitizes tumor cells to NKG2D immune surveillance.
Title: Lysine acetylation of NKG2D ligand Rae-1 stabilizes the protein and sensitizes tumor cells to NKG2D immune surveillance.
Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex.
Title: Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex.
RAE1 and NUP98 participate inBMAL1 shuttling and promote the degradation and activity of BMAL1 and CLOCK.
Title: RAE1 promotes BMAL1 shuttling and regulates degradation and activity of CLOCK: BMAL1 heterodimer.
RAE1 overexpression was associated with considerably poorer disease-free survival and distant metastasis-free survival, especially in patients with oestrogen receptor-positive tumours.
Title: The mitotic checkpoint regulator RAE1 induces aggressive breast cancer cell phenotypes by mediating epithelial-mesenchymal transition.
show that USP11 is associated with the mitotic spindle, does not regulate SAC inactivation, but controls ubiquitination of RAE1 at the mitotic spindle, hereby functionally modulating its interaction with Nuclear Mitotic Apparatus protein (NuMA).
Title: USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation.
Nuclear export inhibition by ORF10 of human herpesvirus 8 requires an interaction with an RNA export factor, Rae1.
Title: A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G06282 (e-PCR)
- UniSTS:77339

G19734 (e-PCR)
- UniSTS:23437

A001X02 (e-PCR)
- UniSTS:23438

A007F20 (e-PCR)
- UniSTS:35793

RH91738 (e-PCR)
- UniSTS:86488

D20S740 (e-PCR)
- UniSTS:47329

NoName (e-PCR)
- UniSTS:486885

Clone Names

FLJ30608, MGC117333, MGC126076, MGC126077

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus	TAS Traceable Author Statement more info	PubMed
involved_in nucleocytoplasmic transport	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	IDA Inferred from Direct Assay more info
located_in mitotic spindle pole	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	TAS Traceable Author Statement more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: mRNA export factor RAE1

Names: RAE1 RNA export 1 homolog; homolog of yeast Rae1 (Bharathi) mRNA-associated protein of 41 kDa (Kraemer); mRNA export factor; mRNA export protein; mRNA-associated protein MRNP 41; mRNA-binding protein, 41-kD; migration-inducing gene 14; rae1 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047090.1 RefSeqGene

Range

5167..33114

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001015885.2 → NP_001015885.1 mRNA export factor RAE1

See identical proteins and their annotated locations for NP_001015885.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR and encodes the same protein, as compared to variant 1.

Source sequence(s)

AI341915, AL109955, AL135939, AY349350, U84720

Consensus CDS

CCDS13458.1

UniProtKB/Swiss-Prot

A8K882, O15306, P78406, Q3SYL7, Q5TCH8, Q6V708, Q9H100, Q9NQM6

UniProtKB/TrEMBL

Q5J8M4

Related

ENSP00000379181.2, ENST00000395840.6

Conserved Domains (2) summary

sd00039
Location:42 → 84

7WD40; WD40 repeat [structural motif]

cl29593
Location:40 → 335

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_003610.4 → NP_003601.1 mRNA export factor RAE1

See identical proteins and their annotated locations for NP_003601.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs from variant 2 in the 5' UTR and encodes the same protein as variant 2.

Source sequence(s)

AI341915, AL109955, AL135939, AY349350, U84720

Consensus CDS

CCDS13458.1

UniProtKB/Swiss-Prot

A8K882, O15306, P78406, Q3SYL7, Q5TCH8, Q6V708, Q9H100, Q9NQM6

UniProtKB/TrEMBL

Q5J8M4

Related

ENSP00000379182.2, ENST00000395841.7

Conserved Domains (2) summary

sd00039
Location:42 → 84

7WD40; WD40 repeat [structural motif]

cl29593
Location:40 → 335

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

57351255..57379202

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005260582.3 → XP_005260639.2 mRNA export factor RAE1 isoform X1

See identical proteins and their annotated locations for XP_005260639.2

UniProtKB/Swiss-Prot

A8K882, O15306, P78406, Q3SYL7, Q5TCH8, Q6V708, Q9H100, Q9NQM6

UniProtKB/TrEMBL

Q5J8M4

Related

ENSP00000360286.2, ENST00000371242.6

Conserved Domains (2) summary

sd00039
Location:42 → 84

7WD40; WD40 repeat [structural motif]

cl29593
Location:40 → 335

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011529087.3 → XP_011527389.1 mRNA export factor RAE1 isoform X2

UniProtKB/TrEMBL

Q5J8M4

Conserved Domains (2) summary

sd00039
Location:42 → 84

7WD40; WD40 repeat [structural motif]

cl29593
Location:40 → 335

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_005260583.3 → XP_005260640.2 mRNA export factor RAE1 isoform X1

UniProtKB/Swiss-Prot

A8K882, O15306, P78406, Q3SYL7, Q5TCH8, Q6V708, Q9H100, Q9NQM6

UniProtKB/TrEMBL

Q5J8M4
XM_011529088.3 → XP_011527390.1 mRNA export factor RAE1 isoform X1

See identical proteins and their annotated locations for XP_011527390.1

UniProtKB/Swiss-Prot

A8K882, O15306, P78406, Q3SYL7, Q5TCH8, Q6V708, Q9H100, Q9NQM6

UniProtKB/TrEMBL

Q5J8M4

Conserved Domains (2) summary

sd00039
Location:42 → 84

7WD40; WD40 repeat [structural motif]

cl29593
Location:40 → 335

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011529089.2 → XP_011527391.1 mRNA export factor RAE1 isoform X1

See identical proteins and their annotated locations for XP_011527391.1

UniProtKB/Swiss-Prot

A8K882, O15306, P78406, Q3SYL7, Q5TCH8, Q6V708, Q9H100, Q9NQM6

UniProtKB/TrEMBL

Q5J8M4

Conserved Domains (2) summary

sd00039
Location:42 → 84

7WD40; WD40 repeat [structural motif]

cl29593
Location:40 → 335

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...