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    SLC15A3 solute carrier family 15 member 3 [ Homo sapiens (human) ]

    Gene ID: 51296, updated on 3-Dec-2024

    Summary

    Official Symbol
    SLC15A3provided by HGNC
    Official Full Name
    solute carrier family 15 member 3provided by HGNC
    Primary source
    HGNC:HGNC:18068
    See related
    Ensembl:ENSG00000110446 MIM:610408; AllianceGenome:HGNC:18068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OCTP; PHT2; PTR3; hPHT2
    Summary
    Enables dipeptide transmembrane transporter activity. Involved in dipeptide import across plasma membrane. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen (RPKM 20.2), lung (RPKM 17.9) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SLC15A3 in Genome Data Viewer
    Location:
    11q12.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (60937084..60952176, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (60888231..60903306, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60704556..60719648, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:60679869-60680867 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:60681866-60682864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4785 Neighboring gene TMEM109 divergent transcript Neighboring gene uncharacterized LOC124902676 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:60686309-60687508 Neighboring gene transmembrane protein 109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3379 Neighboring gene transmembrane protein 132A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4786 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4787 Neighboring gene CD6 molecule Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4788 Neighboring gene RNA, U6 small nuclear 933, pseudogene Neighboring gene tRNA-Ala (TGC) 10-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ26631

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dipeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dipeptide transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide:proton symporter activity TAS
    Traceable Author Statement
    more info
     
    enables peptidoglycan transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in dipeptide import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dipeptide import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic ion transport TAS
    Traceable Author Statement
    more info
     
    involved_in peptidoglycan transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in lysosomal membrane HDA PubMed 
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosomal membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier family 15 member 3
    Names
    osteoclast transporter
    peptide transporter 3
    peptide/histidine transporter 2
    solute carrier family 15 (oligopeptide transporter), member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016582.3NP_057666.1  solute carrier family 15 member 3

      See identical proteins and their annotated locations for NP_057666.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and is protein-coding.
      Source sequence(s)
      AB020598, AP003721, BU731752
      Consensus CDS
      CCDS7998.1
      UniProtKB/Swiss-Prot
      Q8IY34, Q9P2X9
      UniProtKB/TrEMBL
      A0A7P0T8B5
      Related
      ENSP00000227880.2, ENST00000227880.8
      Conserved Domains (1) summary
      cl21472
      Location:175520
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    RNA

    1. NR_027391.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB020598, AP003721, BC025710
      Related
      ENST00000681951.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      60937084..60952176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545095.3XP_011543397.1  solute carrier family 15 member 3 isoform X1

      UniProtKB/TrEMBL
      A0A7P0T8B5, A0A7P0T8H0
      Related
      ENSP00000505077.1, ENST00000681275.1
      Conserved Domains (1) summary
      cl21472
      Location:175520
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    RNA

    1. XR_007062485.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      60888231..60903306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369061.1XP_054225036.1  solute carrier family 15 member 3 isoform X1

      UniProtKB/TrEMBL
      A0A7P0T8B5, A0A7P0T8H0

    RNA

    1. XR_008488403.1 RNA Sequence