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    LANCL2 LanC like glutathione S-transferase 2 [ Homo sapiens (human) ]

    Gene ID: 55915, updated on 3-Dec-2024

    Summary

    Official Symbol
    LANCL2provided by HGNC
    Official Full Name
    LanC like glutathione S-transferase 2provided by HGNC
    Primary source
    HGNC:HGNC:6509
    See related
    Ensembl:ENSG00000132434 MIM:612919; AllianceGenome:HGNC:6509
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TASP; GPR69B
    Summary
    Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in negative regulation of DNA-templated transcription and positive regulation of abscisic acid-activated signaling pathway. Located in several cellular components, including cortical actin cytoskeleton; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 16.9), testis (RPKM 9.1) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See LANCL2 in Genome Data Viewer
    Location:
    7p11.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (55365337..55433737)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (55525667..55594061)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (55433030..55501430)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene calmodulin 1 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:55366838-55367536 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:55378490-55378674 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:55379236-55379736 Neighboring gene RNA exonuclease 1 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26014 Neighboring gene MPRA-validated peak6524 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:55470127-55471114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55495178-55495682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55495683-55496185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26015 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55507999-55508825 Neighboring gene VOPP1 WW domain binding protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55535735-55536236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55540666-55541332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55545601-55546151 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55556042-55556542 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:55560767-55561966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55579955-55580476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55580477-55580998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55584685-55585190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55592347-55592848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26033 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:55606949-55607581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26035 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:55622524-55623470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26038 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18189 Neighboring gene Sharpr-MPRA regulatory region 1113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26041 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55661073-55661572 Neighboring gene VOPP1 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of LANCL2 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC87139

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables GTP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-5-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    lanC-like protein 2
    Names
    G protein-coupled receptor 69B
    LanC (bacterial lantibiotic synthetase component C)-like 2
    LanC lantibiotic synthetase component C-like 2
    LanC like 2
    testis-specific adriamycin sensitivity protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018697.4NP_061167.1  lanC-like protein 2

      See identical proteins and their annotated locations for NP_061167.1

      Status: VALIDATED

      Source sequence(s)
      AC073347
      Consensus CDS
      CCDS5517.1
      UniProtKB/Swiss-Prot
      B2R8D4, Q6NSL4, Q8TCQ3, Q9BSR1, Q9NS86
      UniProtKB/TrEMBL
      B3KTN5
      Related
      ENSP00000254770.2, ENST00000254770.3
      Conserved Domains (1) summary
      cd04794
      Location:103440
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      55365337..55433737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420614.1XP_047276570.1  lanC-like protein 2 isoform X1

      UniProtKB/TrEMBL
      B4DWZ7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      55525667..55594061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)