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    RAB7B RAB7B, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 338382, updated on 27-Nov-2024

    Summary

    Official Symbol
    RAB7Bprovided by HGNC
    Official Full Name
    RAB7B, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:30513
    See related
    Ensembl:ENSG00000276600 AllianceGenome:HGNC:30513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAB7
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Involved in late endosome to Golgi transport; positive regulation of megakaryocyte differentiation; and regulation of gene expression. Located in cytoplasmic vesicle; lysosome; and trans-Golgi network. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in skin (RPKM 15.7), gall bladder (RPKM 6.5) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RAB7B in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (205976740..206003395, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (205240788..205267388, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205889161-205889692 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205889693-205890223 Neighboring gene solute carrier family 26 member 9 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205897002-205897542 Neighboring gene SLC26A9 and RAB7B antisense RNA 1 Neighboring gene uncharacterized LOC103021295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206328947-206329447 Neighboring gene cathepsin E Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206299039-206299540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2395 Neighboring gene uncharacterized LOC105372857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2396 Neighboring gene Sharpr-MPRA regulatory region 5780 Neighboring gene regulator of hemoglobinization and erythroid cell expansion

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1 PubMed
    gag HIV-1 Gag co-localizes with Rab7-, Rab9-, and LAMP1-containing membranes at cytoplasmic and juxtanuclear sites in Staufen1-depleted cells PubMed
    gag HIV-1 Gag mainly remains in endosomes and co-localizes with endosomal protein Rab7 in the cycloheximide-treated cells PubMed
    capsid gag Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC9726, MGC16212

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in phagocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ras-related protein Rab-7b
    Names
    Ras-related protein Rab-7
    NP_001157994.1
    NP_001291768.1
    NP_796377.3
    XP_006711351.1
    XP_054192218.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164522.3NP_001157994.1  ras-related protein Rab-7b isoform a

      See identical proteins and their annotated locations for NP_001157994.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AUXG01000006
      Consensus CDS
      CCDS73011.1
      UniProtKB/Swiss-Prot
      Q96AH8
      Related
      ENSP00000482499.1, ENST00000617070.5
      Conserved Domains (1) summary
      cd00154
      Location:9169
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    2. NM_001304839.2NP_001291768.1  ras-related protein Rab-7b isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AUXG01000006
      Consensus CDS
      CCDS76258.1
      UniProtKB/TrEMBL
      A0A096LP44
      Related
      ENSP00000485386.1, ENST00000623893.1
      Conserved Domains (1) summary
      cd00154
      Location:9132
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    3. NM_177403.6NP_796377.3  ras-related protein Rab-7b isoform a

      See identical proteins and their annotated locations for NP_796377.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AUXG01000006
      Consensus CDS
      CCDS73011.1
      UniProtKB/Swiss-Prot
      Q96AH8
      Related
      ENSP00000479762.1, ENST00000617991.4
      Conserved Domains (1) summary
      cd00154
      Location:9169
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      205976740..206003395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711288.5XP_006711351.1  ras-related protein Rab-7b isoform X1

      Conserved Domains (2) summary
      smart00175
      Location:9174
      RAB; Rab subfamily of small GTPases
      cd00154
      Location:9169
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      205240788..205267388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336243.1XP_054192218.1  ras-related protein Rab-7b isoform X1