BMPR1A bone morphogenetic protein receptor type 1A [Homo sapiens (human)] - Gene

Summary

Official Symbol: BMPR1Aprovided by HGNC
Official Full Name: bone morphogenetic protein receptor type 1Aprovided by HGNC
Primary source: HGNC:HGNC:1076
See related: Ensembl:ENSG00000107779 MIM:601299; AllianceGenome:HGNC:1076
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ALK3; SKR5; ALK-3; CD292; ACVRLK3; BMPR-1A; 10q23del
Summary: The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in thyroid (RPKM 14.8), endometrium (RPKM 10.0) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q23.2

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (86755763..86932844)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (87639833..87816596)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (88515520..88692601)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nonsense suppression induces read-through of a novel BMPR1A variant in a Chinese family with hereditary colorectal cancer.
Title: Nonsense suppression induces read-through of a novel BMPR1A variant in a Chinese family with hereditary colorectal cancer.
ZEB1-AS1 mediates bone metastasis through targeting miR-320b/BMPR1A axis in lung cancer.
Title: ZEB1-AS1 mediates bone metastasis through targeting miR-320b/BMPR1A axis in lung cancer.
Hsa-miR-27b-5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: An ex vivo study.
Title: Hsa-miR-27b-5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: An ex vivo study.
Adenomatous Polyposis Phenotype in BMPR1A and SMAD4 Variant Carriers.
Title: Adenomatous Polyposis Phenotype in BMPR1A and SMAD4 Variant Carriers.
Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation.
Title: Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation.
Bone morphogenetic protein receptor 1alpha promotes osteolytic lesion of oral squamous cell carcinoma by SHH-dependent osteoclastogenesis.
Title: Bone morphogenetic protein receptor 1α promotes osteolytic lesion of oral squamous cell carcinoma by SHH-dependent osteoclastogenesis.
BMP4/ALK3 deficiency leads to Meckel's cartilage truncation mimicking the mandible Tessier 30 cleft.
Title: BMP4/ALK3 deficiency leads to Meckel's cartilage truncation mimicking the mandible Tessier 30 cleft.
Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant.
Title: Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant.
Expression of GALNT8 and O-glycosylation of BMP receptor 1A suppress breast cancer cell proliferation by upregulating ERalpha levels.
Title: Expression of GALNT8 and O-glycosylation of BMP receptor 1A suppress breast cancer cell proliferation by upregulating ERα levels.
Anti-Mullerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival.
Title: Anti-Müllerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival.

Submit: New GeneRIF Correction See all GeneRIFs (90)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Juvenile polyposis syndrome MedGen: C0345893 OMIM: 174900 GeneReviews: Juvenile Polyposis Syndrome	not available
Polyposis syndrome, hereditary mixed, 2 MedGen: C1864730 OMIM: 610069 GeneReviews: Not available	not available

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2020-06-24) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2020-06-24) ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Treatment of pulmonary arterial smooth muscle cells with HIV-1 gp120 downregulates expression of BMPR-2, BMPR-1A, and BMPR-1B proteins	PubMed
Nef	nef	Treatment of pulmonary arterial smooth muscle cells with HIV-1 Nef downregulates expression of BMPR-2, BMPR-1A, and BMPR-1B proteins	PubMed
Tat	tat	Treatment of pulmonary arterial smooth muscle cells with HIV-1 Tat modulates expression of BMPR-2, BMPR-1A, and BMPR-1B proteins	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-147966 (e-PCR)
- UniSTS:176129

RH80090 (e-PCR)
- UniSTS:84511

BMPR1A_487 (e-PCR)
- UniSTS:277037

RH103537 (e-PCR)
- UniSTS:97862

D10S1551E (e-PCR)
- UniSTS:147535

RH93276 (e-PCR)
- UniSTS:89457

D10S231E (e-PCR)
- UniSTS:78456

RH70975 (e-PCR)
- UniSTS:91512

SHGC-148622 (e-PCR)
- UniSTS:176506

D10S1454 (e-PCR)
- UniSTS:83329

STS-N27448 (e-PCR)
- UniSTS:5108

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables BMP binding	IPI Inferred from Physical Interaction more info	PubMed
enables BMP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables BMP receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables SMAD binding	IDA Inferred from Direct Assay more info	PubMed
enables activin receptor activity, type I	IEA Inferred from Electronic Annotation more info
enables activin receptor activity, type II	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transforming growth factor beta receptor activity, type I	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta receptor activity, type I	IDA Inferred from Direct Assay more info	PubMed
enables transforming growth factor beta receptor activity, type II	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity, type III	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein serine/threonine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in BMP signaling pathway	TAS Traceable Author Statement more info
involved_in Mullerian duct regression	IEA Inferred from Electronic Annotation more info
involved_in activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in atrioventricular node cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in atrioventricular valve development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac conduction system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac right ventricle morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to BMP stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in developmental growth	IEA Inferred from Electronic Annotation more info
involved_in dorsal aorta morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in dorsal/ventral axis specification	IEA Inferred from Electronic Annotation more info
involved_in dorsal/ventral pattern formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in ectoderm development	IEA Inferred from Electronic Annotation more info
involved_in embryonic digit morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic organ development	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocardial cushion formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocardial cushion morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in fibrous ring of heart morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart formation	IEA Inferred from Electronic Annotation more info
involved_in hindlimb morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
involved_in lateral mesoderm development	IEA Inferred from Electronic Annotation more info
involved_in lung development	IEA Inferred from Electronic Annotation more info
involved_in mesendoderm development	IEA Inferred from Electronic Annotation more info
involved_in mesoderm formation	IEA Inferred from Electronic Annotation more info
involved_in mitral valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural crest cell development	IEA Inferred from Electronic Annotation more info
involved_in neural plate mediolateral regionalization	IEA Inferred from Electronic Annotation more info
involved_in odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in outflow tract septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in paraxial mesoderm structural organization	IEA Inferred from Electronic Annotation more info
involved_in pharyngeal arch artery morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in pituitary gland development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac ventricle development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendrite development	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mesenchymal cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of transforming growth factor beta2 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of cardiac muscle cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cardiac muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular senescence	IEA Inferred from Electronic Annotation more info
involved_in regulation of lateral mesodermal cell fate specification	IEA Inferred from Electronic Annotation more info
NOT involved_in regulation of neural crest cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in roof of mouth development	IEA Inferred from Electronic Annotation more info
involved_in somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in somitogenesis	IEA Inferred from Electronic Annotation more info
involved_in stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tricuspid valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ventricular compact myocardium morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ventricular septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ventricular trabecula myocardium morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of HFE-transferrin receptor complex	IC Inferred by Curator more info	PubMed
colocalizes_with caveola	IMP Inferred from Mutant Phenotype more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bone morphogenetic protein receptor type-1A

Names: BMP type-1A receptor; activin A receptor, type II-like kinase 3; activin receptor-like kinase 3; bone morphogenetic protein receptor, type IA; serine/threonine-protein kinase receptor R5

NP_001393488.1

EC 2.7.11.30

NP_001393489.1

EC 2.7.11.30

NP_001393490.1

EC 2.7.11.30

NP_001393491.1

EC 2.7.11.30

NP_001393492.1

EC 2.7.11.30

NP_001393493.1

EC 2.7.11.30

NP_001393494.1

EC 2.7.11.30

NP_001393495.1

EC 2.7.11.30

NP_001393496.1

EC 2.7.11.30

NP_001393497.1

EC 2.7.11.30

NP_001393498.1

EC 2.7.11.30

NP_001393499.1

EC 2.7.11.30

NP_001393500.1

EC 2.7.11.30

NP_001393501.1

EC 2.7.11.30

NP_001393502.1

EC 2.7.11.30

NP_001393503.1

EC 2.7.11.30

NP_001393504.1

EC 2.7.11.30

NP_001393505.1

EC 2.7.11.30

NP_001393506.1

EC 2.7.11.30

NP_001393507.1

EC 2.7.11.30

NP_001393508.1

EC 2.7.11.30

NP_001393509.1

EC 2.7.11.30

NP_001393510.1

EC 2.7.11.30

NP_001393511.1

EC 2.7.11.30

NP_001393512.1

EC 2.7.11.30

NP_001393513.1

EC 2.7.11.30

NP_001393514.1

EC 2.7.11.30

NP_001393515.1

EC 2.7.11.30

NP_001393516.1

EC 2.7.11.30

NP_001393517.1

EC 2.7.11.30

NP_001393518.1

EC 2.7.11.30

NP_004320.2

EC 2.7.11.30

XP_047281636.1

EC 2.7.11.30

XP_054222620.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009362.1 RefSeqGene

Range

5001..173550

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_298

mRNA and Protein(s)

NM_001406559.1 → NP_001393488.1 bone morphogenetic protein receptor type-1A isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/TrEMBL

B5BUG9
NM_001406560.1 → NP_001393489.1 bone morphogenetic protein receptor type-1A isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/TrEMBL

B5BUG9
NM_001406561.1 → NP_001393490.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

Consensus CDS

CCDS7378.1

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9

Related

ENSP00000483569.2, ENST00000480152.3
NM_001406562.1 → NP_001393491.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

Consensus CDS

CCDS7378.1

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406563.1 → NP_001393492.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

Consensus CDS

CCDS7378.1

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406564.1 → NP_001393493.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

Consensus CDS

CCDS7378.1

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406565.1 → NP_001393494.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406566.1 → NP_001393495.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

Consensus CDS

CCDS7378.1

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406567.1 → NP_001393496.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406568.1 → NP_001393497.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

Consensus CDS

CCDS7378.1

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9

Related

ENSP00000518971.1, ENST00000713669.1
NM_001406569.1 → NP_001393498.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406570.1 → NP_001393499.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406571.1 → NP_001393500.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406572.1 → NP_001393501.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406573.1 → NP_001393502.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406574.1 → NP_001393503.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406575.1 → NP_001393504.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406576.1 → NP_001393505.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406577.1 → NP_001393506.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406578.1 → NP_001393507.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9

Related

ENSP00000518977.1, ENST00000713675.1
NM_001406579.1 → NP_001393508.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406580.1 → NP_001393509.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406581.1 → NP_001393510.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406582.1 → NP_001393511.1 bone morphogenetic protein receptor type-1A isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9
NM_001406583.1 → NP_001393512.1 bone morphogenetic protein receptor type-1A isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/TrEMBL

B5BUG9
NM_001406584.1 → NP_001393513.1 bone morphogenetic protein receptor type-1A isoform 5

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/TrEMBL

B5BUG9
NM_001406585.1 → NP_001393514.1 bone morphogenetic protein receptor type-1A isoform 5

Status: REVIEWED

Source sequence(s)

AC025268, AC067750

UniProtKB/TrEMBL

B5BUG9
NM_001406586.1 → NP_001393515.1 bone morphogenetic protein receptor type-1A isoform 5

Status: REVIEWED

Source sequence(s)

AC025268, AC067750

UniProtKB/TrEMBL

B5BUG9
NM_001406587.1 → NP_001393516.1 bone morphogenetic protein receptor type-1A isoform 5

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/TrEMBL

B5BUG9
NM_001406588.1 → NP_001393517.1 bone morphogenetic protein receptor type-1A isoform 5

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

UniProtKB/TrEMBL

B5BUG9

Related

ENSP00000518975.1, ENST00000713673.1
NM_001406589.1 → NP_001393518.1 bone morphogenetic protein receptor type-1A isoform 6 precursor

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750
NM_004329.3 → NP_004320.2 bone morphogenetic protein receptor type-1A isoform 3 precursor

See identical proteins and their annotated locations for NP_004320.2

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

Consensus CDS

CCDS7378.1

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9

Related

ENSP00000361107.2, ENST00000372037.8

Conserved Domains (3) summary

smart00221
Location:234 → 521

STYKc; Protein kinase; unclassified specificity

cd14220
Location:238 → 524

STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor

pfam01064
Location:59 → 138

Activin_recp; Activin types I and II receptor domain

RNA

NR_176211.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750
NR_176212.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750
NR_176213.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC021036, AC025268, AC067750

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

86755763..86932844

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047425680.1 → XP_047281636.1 bone morphogenetic protein receptor type-1A isoform X1

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

87639833..87816596

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054366645.1 → XP_054222620.1 bone morphogenetic protein receptor type-1A isoform X1

UniProtKB/Swiss-Prot

A8K6U9, P36894, Q8NEN8

UniProtKB/TrEMBL

B5BUG9