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    MYH1 myosin heavy chain 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281337, updated on 30-Jan-2025

    Summary

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    Official Symbol
    MYH1provided by VGNC
    Official Full Name
    myosin heavy chain 1provided by VGNC
    Primary source
    VGNC:VGNC:55851
    See related
    BGD:BT11126; EnsemblRapid:ENSBTAG00070019341
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MYH1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (29483025..29507355, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene myosin heavy chain 8 Neighboring gene myosin-1-like Neighboring gene myosin heavy chain 4 Neighboring gene myosin heavy chain 2 Neighboring gene myosin heavy chain 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Gene and protein expression of myosin heavy chain in Nellore cattle comparing growth or meat tenderness traits. Chardulo LAL, et al. Anim Biotechnol, 2021 Jun. PMID 31702438
    2. Differences in mitochondrial gene expression profiles, enzyme activities and myosin heavy chain types in yak versus bovine skeletal muscles. Lin YQ, et al. Genet Mol Res, 2012 Aug 29. PMID 22653670
    3. Myosin heavy chain isoforms expressed in bovine skeletal muscles. Chikuni K, et al. Meat Sci, 2004 May. PMID 22061120
    4. Sequencing of the 2a, 2x, and slow isoforms of the bovine myosin heavy chain and the different expression among muscles. Tanabe R, et al. Mamm Genome, 1998 Dec. PMID 9880677
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gene and protein expression of myosin heavy chain in Nellore cattle comparing growth or meat tenderness traits.
      Title: Gene and protein expression of myosin heavy chain in Nellore cattle comparing growth or meat tenderness traits.
    2. The yak has significantly lower mRNA levels of CPT, UCP3, and MyHC 1 in biceps femoris than in Yellow cattle.
      Title: Differences in mitochondrial gene expression profiles, enzyme activities and myosin heavy chain types in yak versus bovine skeletal muscles.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables microfilament motor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of myosin II complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myosin-1
    Names
    myHC-2x
    myosin heavy chain 2x
    myosin heavy chain, skeletal muscle, adult 1
    myosin, heavy chain 1, skeletal muscle, adult
    myosin, heavy polypeptide 1, skeletal muscle, adult
    type 2x myosin heavy chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174117.1 → NP_776542.1  myosin-1

      See identical proteins and their annotated locations for NP_776542.1

      Status: PROVISIONAL

      Source sequence(s)
      AB059399
      UniProtKB/Swiss-Prot
      Q9BE40
      UniProtKB/TrEMBL
      E1BP87
      Related
      ENSBTAP00070026306.1, ENSBTAT00070043741.1
      Conserved Domains (3) summary
      cd01377
      Location:100 → 769
      MYSc_class_II; class II myosins, motor domain
      pfam02736
      Location:35 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      cl25732
      Location:849 → 1926
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      29483025..29507355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010815980.4 → XP_010814282.1  myosin-1 isoform X1

      See identical proteins and their annotated locations for XP_010814282.1

      UniProtKB/Swiss-Prot
      Q9BE40
      UniProtKB/TrEMBL
      E1BP87
      Conserved Domains (3) summary
      cd01377
      Location:100 → 769
      MYSc_class_II; class II myosins, motor domain
      pfam02736
      Location:35 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      cl25732
      Location:849 → 1926
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BE40.2 GenPept UniProtKB/Swiss-Prot:Q9BE40

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials