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    MACF1 microtubule actin crosslinking factor 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 506730, updated on 1-Jan-2025

    Summary

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    Official Symbol
    MACF1provided by VGNC
    Official Full Name
    microtubule actin crosslinking factor 1provided by VGNC
    Primary source
    VGNC:VGNC:55610
    See related
    BGD:BT19411; Ensembl:ENSBTAG00000021024
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ACF7
    NEW
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    Genomic context

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    See MACF1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    108
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (106589750..106930676, complement)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA55 Neighboring gene poly(A) binding protein cytoplasmic 4 Neighboring gene succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial Neighboring gene bone morphogenetic protein 8a Neighboring gene KIAA0754 ortholog Neighboring gene microRNA mir-2416 Neighboring gene U2 spliceosomal RNA Neighboring gene rho-related GTP-binding protein RhoG-like Neighboring gene NADH:ubiquinone oxidoreductase subunit S5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intermediate filament cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microtubule-actin cross-linking factor 1
    Names
    actin-crosslinking protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143860.3 → NP_001137332.3  microtubule-actin cross-linking factor 1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000003
      UniProtKB/TrEMBL
      A0A3Q1ME09
      Related
      ENSBTAP00000069208.2, ENSBTAT00000087050.2

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      106589750..106930676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059882785.1 → XP_059738768.1  microtubule-actin cross-linking factor 1 isoform X16

      UniProtKB/TrEMBL
      A0A3Q1ME09

    2. XM_059882784.1 → XP_059738767.1  microtubule-actin cross-linking factor 1 isoform X15

      UniProtKB/TrEMBL
      A0A3Q1ME09

    3. XM_059882759.1 → XP_059738742.1  microtubule-actin cross-linking factor 1 isoform X3

      UniProtKB/TrEMBL
      A0AAA9T0L5

    4. XM_059882780.1 → XP_059738763.1  microtubule-actin cross-linking factor 1 isoform X14

      UniProtKB/TrEMBL
      A0AAA9S484, F1N6H4
      Related
      ENSBTAP00000033188.6, ENSBTAT00000033270.6

    5. XM_059882773.1 → XP_059738756.1  microtubule-actin cross-linking factor 1 isoform X12

      UniProtKB/TrEMBL
      A0AAA9T0L5

    6. XM_024986594.2 → XP_024842362.1  microtubule-actin cross-linking factor 1 isoform X11

      UniProtKB/TrEMBL
      A0AAA9S484
      Related
      ENSBTAP00000103863.1, ENSBTAT00000135503.1
      Conserved Domains (10) summary
      smart00243
      Location:7191 → 7263
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:586 → 680
      SPEC; Spectrin repeats
      COG5069
      Location:73 → 297
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:6736 → 6948
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:1769 → 1809
      Plectin; Plectin repeat
      pfam13499
      Location:7114 → 7177
      EF-hand_7; EF-hand domain pair
      cl02488
      Location:4981 → 5194
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl25732
      Location:4072 → 4995
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:2018 → 2235
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28033
      Location:7316 → 7457
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    7. XM_059882762.1 → XP_059738745.1  microtubule-actin cross-linking factor 1 isoform X5

      UniProtKB/TrEMBL
      A0AAA9T0L5

    8. XM_059882757.1 → XP_059738740.1  microtubule-actin cross-linking factor 1 isoform X2

      UniProtKB/TrEMBL
      A0AAA9T0L5

    9. XM_059882770.1 → XP_059738753.1  microtubule-actin cross-linking factor 1 isoform X10

      UniProtKB/TrEMBL
      A0AAA9S484
      Related
      ENSBTAP00000079658.1, ENSBTAT00000119208.1

    10. XM_059882760.1 → XP_059738743.1  microtubule-actin cross-linking factor 1 isoform X4

      UniProtKB/TrEMBL
      A0AAA9T0L5

    11. XM_024986555.2 → XP_024842323.1  microtubule-actin cross-linking factor 1 isoform X6

      UniProtKB/TrEMBL
      A0AAA9T0L5
      Conserved Domains (10) summary
      smart00150
      Location:586 → 680
      SPEC; Spectrin repeats
      COG5069
      Location:73 → 297
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:6736 → 6948
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:1769 → 1809
      Plectin; Plectin repeat
      pfam02187
      Location:7193 → 7267
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam13499
      Location:7114 → 7177
      EF-hand_7; EF-hand domain pair
      cl02488
      Location:4981 → 5194
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl25732
      Location:4072 → 4995
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:2018 → 2235
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28033
      Location:7347 → 7486
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    12. XM_059882756.1 → XP_059738739.1  microtubule-actin cross-linking factor 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9T0L5
      Related
      ENSBTAP00000091240.1, ENSBTAT00000122649.1

    13. XM_059882767.1 → XP_059738750.1  microtubule-actin cross-linking factor 1 isoform X8

      UniProtKB/TrEMBL
      A0AAA9S484
      Related
      ENSBTAP00000078616.1, ENSBTAT00000097461.1

    14. XM_059882763.1 → XP_059738746.1  microtubule-actin cross-linking factor 1 isoform X7

      UniProtKB/TrEMBL
      A0AAA9TYZ5

    15. XM_059882775.1 → XP_059738758.1  microtubule-actin cross-linking factor 1 isoform X13

      UniProtKB/TrEMBL
      A0AAA9RTB7, A0AAA9TYZ5
      Related
      ENSBTAP00000076149.1, ENSBTAT00000107508.1

    16. XM_059882769.1 → XP_059738752.1  microtubule-actin cross-linking factor 1 isoform X9

      UniProtKB/TrEMBL
      A0AAA9TQ00
    Nucleotide Protein Strain
    Heading Accession and Version

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