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    MAP2 microtubule associated protein 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281294, updated on 27-Dec-2024

    Summary

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    Official Symbol
    MAP2provided by VGNC
    Official Full Name
    microtubule associated protein 2provided by VGNC
    Primary source
    VGNC:VGNC:31182
    See related
    BGD:BT21488; Ensembl:ENSBTAG00000018130
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MAP2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (97263457..97562142)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene protein salvador homolog 1-like Neighboring gene uncharacterized LOC132343579 Neighboring gene unc-80 homolog, NALCN channel complex subunit Neighboring gene KAT8 regulatory NSL complex subunit 1 like Neighboring gene ribulose-5-phosphate-3-epimerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Exploring the microtubule-binding region of bovine microtubule-associated protein-2 (MAP-2): cDNA sequencing, bacterial expression, and site-directed mutagenesis. Coffey RL, et al. Biochemistry, 1994 Nov 15. PMID 7947727
    2. The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies. Sontag JM, et al. J Biol Chem, 2012 Apr 27. PMID 22403409, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn.
      Title: The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microtubule-associated protein 2
    Names
    microtubule associated protein 2C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205807.1 → NP_001192736.1  microtubule-associated protein 2

      See identical proteins and their annotated locations for NP_001192736.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000002
      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1701 → 1730
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1515
      MAP2_projctn; MAP2/Tau projection domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      97263457..97562142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010802225.4 → XP_010800527.1  microtubule-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_010800527.1

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1842 → 1871
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:461 → 1599
      MAP2_projctn; MAP2/Tau projection domain

    2. XM_024998329.2 → XP_024854097.1  microtubule-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1842 → 1871
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:461 → 1599
      MAP2_projctn; MAP2/Tau projection domain

    3. XM_024998302.2 → XP_024854070.1  microtubule-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1842 → 1871
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:461 → 1599
      MAP2_projctn; MAP2/Tau projection domain

    4. XM_005202699.5 → XP_005202756.1  microtubule-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005202756.1

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1842 → 1871
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:461 → 1599
      MAP2_projctn; MAP2/Tau projection domain

    5. XM_010802230.4 → XP_010800532.1  microtubule-associated protein 2 isoform X5

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1842 → 1871
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:461 → 1599
      MAP2_projctn; MAP2/Tau projection domain

    6. XM_010802231.4 → XP_010800533.1  microtubule-associated protein 2 isoform X6

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1785 → 1814
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:461 → 1599
      MAP2_projctn; MAP2/Tau projection domain

    7. XM_010802234.4 → XP_010800536.1  microtubule-associated protein 2 isoform X9

      UniProtKB/TrEMBL
      F1MEW3
      Related
      ENSBTAP00000024134.6, ENSBTAT00000024134.6
      Conserved Domains (2) summary
      pfam00418
      Location:1785 → 1814
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:461 → 1599
      MAP2_projctn; MAP2/Tau projection domain

    8. XM_010802228.4 → XP_010800530.1  microtubule-associated protein 2 isoform X4

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1841 → 1870
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:461 → 1599
      MAP2_projctn; MAP2/Tau projection domain

    9. XM_010802232.4 → XP_010800534.1  microtubule-associated protein 2 isoform X7

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1784 → 1813
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:461 → 1599
      MAP2_projctn; MAP2/Tau projection domain

    10. XM_059891367.1 → XP_059747350.1  microtubule-associated protein 2 isoform X11

      UniProtKB/TrEMBL
      F1MEW3

    11. XM_015458760.3 → XP_015314246.1  microtubule-associated protein 2 isoform X2

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1841 → 1870
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:461 → 1598
      MAP2_projctn; MAP2/Tau projection domain

    12. XM_059891372.1 → XP_059747355.1  microtubule-associated protein 2 isoform X12

      UniProtKB/TrEMBL
      F1MEW3

    13. XM_024998376.2 → XP_024854144.1  microtubule-associated protein 2 isoform X13

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1783 → 1812
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:461 → 1598
      MAP2_projctn; MAP2/Tau projection domain

    14. XM_010802233.4 → XP_010800535.1  microtubule-associated protein 2 isoform X8

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1758 → 1787
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1515
      MAP2_projctn; MAP2/Tau projection domain

    15. XM_024998381.2 → XP_024854149.1  microtubule-associated protein 2 isoform X14

      UniProtKB/TrEMBL
      A0A3Q1NAK9, F1MEW3
      Related
      ENSBTAP00000068316.2, ENSBTAT00000071341.2
      Conserved Domains (2) summary
      pfam00418
      Location:1701 → 1730
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1515
      MAP2_projctn; MAP2/Tau projection domain

    16. XM_059891386.1 → XP_059747369.1  microtubule-associated protein 2 isoform X17

      UniProtKB/TrEMBL
      F1MEW3

    17. XM_059891385.1 → XP_059747368.1  microtubule-associated protein 2 isoform X16

      UniProtKB/TrEMBL
      F1MEW3

    18. XM_059891380.1 → XP_059747363.1  microtubule-associated protein 2 isoform X15

      UniProtKB/TrEMBL
      F1MEW3

    19. XM_010802237.4 → XP_010800539.1  microtubule-associated protein 2 isoform X19

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1697 → 1726
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:373 → 1511
      MAP2_projctn; MAP2/Tau projection domain

    20. XM_059891396.1 → XP_059747379.1  microtubule-associated protein 2 isoform X21

      UniProtKB/TrEMBL
      F1MEW3

    21. XM_059891392.1 → XP_059747375.1  microtubule-associated protein 2 isoform X20

      UniProtKB/TrEMBL
      F1MEW3

    22. XM_010802238.4 → XP_010800540.1  microtubule-associated protein 2 isoform X23

      See identical proteins and their annotated locations for XP_010800540.1

      UniProtKB/TrEMBL
      A0A3Q1MQE4
      Related
      ENSBTAP00000071956.1, ENSBTAT00000080758.2
      Conserved Domains (2) summary
      pfam00418
      Location:392 → 421
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl25751
      Location:108 → 388
      DUF4045; Domain of unknown function (DUF4045)

    23. XM_059891412.1 → XP_059747395.1  microtubule-associated protein 2 isoform X25

    24. XM_010802240.4 → XP_010800542.1  microtubule-associated protein 2 isoform X26

      See identical proteins and their annotated locations for XP_010800542.1

      Conserved Domains (2) summary
      pfam00418
      Location:335 → 364
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl25751
      Location:110 → 300
      DUF4045; Domain of unknown function (DUF4045)

    25. XM_010802241.4 → XP_010800543.1  microtubule-associated protein 2 isoform X27

      See identical proteins and their annotated locations for XP_010800543.1

      Conserved Domains (2) summary
      pfam00418
      Location:335 → 364
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl25751
      Location:110 → 300
      DUF4045; Domain of unknown function (DUF4045)

    26. XM_059891409.1 → XP_059747392.1  microtubule-associated protein 2 isoform X24

    27. XM_059891418.1 → XP_059747401.1  microtubule-associated protein 2 isoform X28

    28. XM_024998347.2 → XP_024854115.1  microtubule-associated protein 2 isoform X3

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1841 → 1870
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:460 → 1598
      MAP2_projctn; MAP2/Tau projection domain

    29. XM_059891435.1 → XP_059747418.1  microtubule-associated protein 2 isoform X32

      UniProtKB/TrEMBL
      F1MEW3

    30. XM_059891431.1 → XP_059747414.1  microtubule-associated protein 2 isoform X31

      UniProtKB/TrEMBL
      F1MEW3

    31. XM_059891388.1 → XP_059747371.1  microtubule-associated protein 2 isoform X18

      UniProtKB/TrEMBL
      F1MEW3

    32. XM_059891405.1 → XP_059747388.1  microtubule-associated protein 2 isoform X22

      UniProtKB/TrEMBL
      F1MEW3

    33. XM_059891424.1 → XP_059747407.1  microtubule-associated protein 2 isoform X29

    34. XM_059891429.1 → XP_059747412.1  microtubule-associated protein 2 isoform X30

    35. XM_059891337.1 → XP_059747320.1  microtubule-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      F1MEW3

    36. XM_059891324.1 → XP_059747307.1  microtubule-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      F1MEW3

    37. XM_005202698.5 → XP_005202755.1  microtubule-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005202755.1

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1842 → 1871
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:461 → 1599
      MAP2_projctn; MAP2/Tau projection domain

    38. XM_059891355.1 → XP_059747338.1  microtubule-associated protein 2 isoform X8

      UniProtKB/TrEMBL
      F1MEW3

    39. XM_059891365.1 → XP_059747348.1  microtubule-associated protein 2 isoform X10

      UniProtKB/TrEMBL
      F1MEW3

    40. XM_024998369.2 → XP_024854137.1  microtubule-associated protein 2 isoform X8

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1758 → 1787
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:377 → 1515
      MAP2_projctn; MAP2/Tau projection domain

    41. XM_024998373.2 → XP_024854141.1  microtubule-associated protein 2 isoform X10

      UniProtKB/TrEMBL
      F1MEW3
      Conserved Domains (2) summary
      pfam00418
      Location:1754 → 1783
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:373 → 1511
      MAP2_projctn; MAP2/Tau projection domain

    42. XM_024998388.2 → XP_024854156.1  microtubule-associated protein 2 isoform X26

      Conserved Domains (2) summary
      pfam00418
      Location:335 → 364
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl25751
      Location:110 → 300
      DUF4045; Domain of unknown function (DUF4045)

    43. XM_024998393.2 → XP_024854161.1  microtubule-associated protein 2 isoform X27

      Conserved Domains (2) summary
      pfam00418
      Location:335 → 364
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl25751
      Location:110 → 300
      DUF4045; Domain of unknown function (DUF4045)
    Nucleotide Protein Strain
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