MMACHC metabolism of cobalamin associated C [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: MMACHCprovided by VGNC
Official Full Name: metabolism of cobalamin associated Cprovided by VGNC
Primary source: VGNC:VGNC:57129
See related: BGD:BT27608; EnsemblRapid:ENSBTAG00070003906
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: cblC
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (100566188..100571190, complement)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

bCblCpro,a bovine homolog of a human B trafficking chaperone appears to be very sensitive to thermal denaturation, indicating that thermolability is a common property of CblC proteins.
Title: Glutathione and vitamin B₁₂ cooperate in stabilization of a B₁₂ trafficking chaperone protein.
These results suggest that GSSG is a negative regulator of bCblCpro and that the molar ratio of [GSH]/[GSSG] in cells may determine the stability of the B(12) trafficking chaperone.
Title: Destabilization of a bovine B₁₂ trafficking chaperone protein by oxidized form of glutathione.
The results of this study suggest that GSH positively modulates bCblC by increasing the binding affinity for CNCbl, which would enhance functional efficiency of the protein.
Title: Glutathione increases the binding affinity of a bovine B₁₂ trafficking chaperone bCblC for vitamin B₁₂.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity	IEA Inferred from Electronic Annotation more info	PubMed
enables demethylase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cobalamin metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: cyanocobalamin reductase / alkylcobalamin dealkylase

Names: alkylcobalamin:glutathione S-alkyltransferase; cyanocobalamin reductase (cyanide-eliminating); methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; methylmalonic aciduria and homocystinuria type C homolog; methylmalonic aciduria and homocystinuria type C protein homolog

NP_001015588.2

EC 1.16.1.6

EC 2.5.1.151

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.