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    ARHGAP42 Rho GTPase activating protein 42 [ Bos taurus (domestic cattle) ]

    Gene ID: 508009, updated on 30-Jan-2025

    Summary

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    Official Symbol
    ARHGAP42provided by VGNC
    Official Full Name
    Rho GTPase activating protein 42provided by VGNC
    Primary source
    VGNC:VGNC:26096
    See related
    EnsemblRapid:ENSBTAG00070015383
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGAP42 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (8003637..8351659, complement)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene adenosylhomocysteinase-like Neighboring gene progesterone receptor Neighboring gene ubiquitin-related modifier 1-like Neighboring gene uncharacterized LOC112441562 Neighboring gene 60S ribosomal protein L6 pseudogene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32810

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho GTPase-activating protein 10-like; rho GTPase-activating protein 42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      8003637..8351659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003586932.6 → XP_003586980.1  rho GTPase-activating protein 42 isoform X1

      See identical proteins and their annotated locations for XP_003586980.1

      UniProtKB/TrEMBL
      A0A3Q1LL23, A0A3Q1MT43
      Related
      ENSBTAP00070020560.1, ENSBTAT00070034898.1
      Conserved Domains (5) summary
      cd07634
      Location:19 → 225
      BAR_GAP10-like; The Bin/Amphiphysin/Rvs (BAR) domain of Rho GTPase activating protein 10-like
      cd12066
      Location:820 → 874
      SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
      cd04374
      Location:369 → 567
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 376
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 369
      PH; PH domain

    2. XM_059875064.1 → XP_059731047.1  rho GTPase-activating protein 42 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MIB3, A0AAA9S632
      Related
      ENSBTAP00070020546.1, ENSBTAT00070034849.1

    3. XM_059875065.1 → XP_059731048.1  rho GTPase-activating protein 42 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LFB4, A0AAA9S632

    4. XM_024975717.2 → XP_024831485.1  rho GTPase-activating protein 42 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LFB4, A0AAA9S632
      Related
      ENSBTAP00070020556.1, ENSBTAT00070034879.1
      Conserved Domains (4) summary
      cd12066
      Location:766 → 820
      SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
      cd04374
      Location:315 → 513
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:213 → 322
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:1 → 171
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001075343.1: Suppressed sequence

      Description
      NM_001075343.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: ARHGAP42 (GeneID:143872).
    Nucleotide Protein Strain
    Heading Accession and Version

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